Stephen Moore scored his first County Championship century for Lancashire to secure a six-wicket victory over Nottinghamshire on the final day at Trent Bridge.
Requiring 237 to win, Moore struck an unbeaten 129 from 208 balls on a tricky pitch with variable bounce to condemn the defending champions to their fourth straight defeat.
Resuming their second innings on 32-0, Lancashire openers Moore and Paul Horton survived the opening half-hour before Horton (30) edged Charlie Shreck to David Hussey at second slip.
Eight overs later Shreck, who finished with figures of 3-54, claimed his second scalp, dismissing Karl Brown lbw for 17.
Moore went on to share a 90-run partnership for the third wicket with Mark Chilton before Andre Adams had Chilton lbw for 35.
He clinched his first century for almost two years with a cut for four off Shreck, who grabbed his third wicket when Steven Croft gave Hussey another slip catch.
But with just 11 more runs required, nothing could prevent title-chasing Lancashire from claiming their first Championship win at Trent Bridge since 2006.
Lancashire ended day three at Trent Bridge on 32-0 after Sajid Mahmood's 10-wicket haul left them chasing 237 for victory against Nottinghamshire.
Paceman Mahmood claimed 5-74, his best figures of the season so far, in the home side's second innings to finish with 10-186 in the match.
His most crucial breakthrough came when he removed Andre Adams (52) to end a stubborn eighth-wicket stand of 119 with Paul Franks, who made 57.
Nottinghamshire had been indebted to the pair of all-rounders for getting them out of a serious hole after they slumped to 81-7 when skipper Chris Read became the fourth victim for seamer Kyle Hogg.
Having mopped up the final two Lancashire wickets in the morning to gain a lead of 20, the reigning Division One champions saw their top order once again collapse in a heap.
Opener Riki Wessels did make 35 but it needed half-centuries from Franks and Adams, who hit three sixes and five fours, to give Notts' bowlers anything to work with in the final innings of the contest.
Left to face 13 overs, Lancashire's opening duo of Paul Horton and Stephen Moore survived through to the close to leave Lancashire in pole position.
Opener Paul Horton fell agonisingly short of his first County Championship century since April 2010 as Lancashire closed to within 33 of Nottinghamshire's first-innings total of 326 at Trent Bridge.
After sharing an opening partnership of 82 with Stephen Moore (42) the 28-year-old right-hander pushed on to 99 before becoming the last of four victims for Paul Franks.
Moore was the first to go, slashing at a wide Luke Fletcher delivery to edge a simple catch to wicketkeeper Chris Read. And six overs later Karl Brown (10) followed when he edged a good ball from Fletcher to Alex Hales at slip.
Franks was star performer with the ball for the hosts though, scything through Lancashire's middle order and then removing Horton to finish with 4-50 from 22 overs.
The all-rounder, who top-scored on day one with 69, first bowled Mark Chilton (24) before dismissing Steven Croft and Tom Smith for two and six respectively.
Horton became the seventh wicket to fall and Maharoof was dismissed for 13 to leave Lancashire on 243-8.
But Sajid Mahmood (39no) added an unbroken 50 for the ninth wicket with Kyle Hogg (19no) to push the visitors on to 293-8 at the close.
Nottinghamshire were once again indebted to their lower order as they recovered from 138-6 to make 326 on day one against Lancashire.
Alex Hales (51) and Samit Patel (52) both hit half-centuries for the hosts, who had won the toss and opted to bat first, at Trent Bridge.
However the innings subsided rapidly once Hales departed, leaving Chris Read and Paul Franks to steady the ship with a stand of 135 in 46 overs.
Skipper Read hit five fours and a six in his 134-ball innings of 58, while Franks made 69 from 156 deliveries with nine fours. The pair were then both been dismissed in the same over by Sajid Mahmood, who finished with 5-112.
However Andre Adams continued the fightback with a whirlwind knock of 43 that included no less than five sixes. He faced just 27 balls for his runs before being caught at deep point, bringing an end to the innings.
Lancashire openers openers Paul Horton and Stephen Moore survived the last two overs of an enthralling day, meaning the Red Rose county will resume on Tuesday on 7-0.