Defending champions Sussex will be without both Mushtaq Ahmed and Luke Wright for their trip to the Rose Bowl.
Leg spinner Mushtaq, such a key man in the county's success last season, sits out the match as he continues his recovery from a second knee operation.
All-rounder Wright is also sidelined having broken a finger while taking part in fielding practice with England during the first Test at Lord's.
Sussex will decide between either 19-year-old leg-spinner Will Beer or Rageb Aga to come into the team.
Hosts Hampshire have selection problems of their own with former South Africa paceman Nantie Hayward once again ruled out.
His fellow countryman Rory Kleinveldt looks set to continue in his absence, while Kevin Pietersen is once again away on international duty.
Dimitri Mascarenhas' side currently sit bottom of Division One after losing on home soil to Lancashire last time out.