Warwickshire duo Jim Troughton and Naqaash Tahir are in line for their first Championship appearances of the season against Middlesex.
Troughton is available after overcoming a back injury, while Tahir is fit again following a shin splints problem.
The absence of Ian Bell and Tim Ambrose on England duty, provides the duo with a route back into Warwickshire's four-day side.
Tony Frost made a quickfire 56 against Ireland in the FP Trophy last Friday and will keep wicket again in place of Ambrose.
South African paceman Monde Zondeki will play but his time wth at Edgbaston could be shorter than expected after he was handed a national contract by South Africa - an indication that he is likely to be required by the Proteas for the upcoming Test series against England in July.
Navdeep Poonia again has to settle for a spot in the second XI, despite scoring 111 and 50 against Cambridge UCCE.
Middlesex look set to hand a debut to Dirk Nannes as they attempt to reverse a worrying run of form in the longer format.
Ed Smith's men are bottom of Division Two having lost twice in their opening three Championship fixtures.
Nannes, an Australian left-arm seamer who qualifies through a Dutch passport, comes in for Steven Finn, who struggled during the defeat to Essex last time out.
Chris Silverwood is still sidelined with knee problems and Andrew Strauss is away on England duty.