Matthew Hayden has been ruled out of the remainder of Australia's tour of West Indies due to an Achilles injury.
The opening batsman, 36, missed the series-opener in Jamaica due to the problem but it had been hoped he may recover in time for the second at the Sir Vivian Richards Stadium.
However, the injury has not responded to treatment and Hayden will now miss the final two Tests and the five-match one-day international series that follows.
The news is a blow to Australia's hopes of sealing the Test series in Antigua following their 95-run victory in the first Test.
Phil Jaques and Simon Katich will continue to open the innings in Hayden's absence - despite providing an aggregate of just 13 runs in each innings of the first Test.
Clarke in for Hodge
"In both innings (in Jamaica), we lost wickets early and to be four down for 18 in the second innings was a worry," Australia captain Ricky Ponting said.
"But there was some good bowling in there. It was a situation where it was an unsettling sort of time to have to bat, only an hour left in the [fourth] day's play, just trying to get through the session rather than playing your natural game.
"But I think that showed that the West Indies bowling attack is going to be dangerous, especially with the new ball. If we can get through this, we should be okay."
Michael Clarke returns to the batting line-up after joining up with the squad late due to the death of his partner's father.
Brad Hodge will make way for Clarke, however following Hayden's injury, Cricket Australia have revealed the Victorian will remain in the squad for the rest of the tour.
WIndies team news
West Indies have received a double boost ahead of the second Test with the return of regular captain Chris Gayle and key fast bowler Taylor.
Gayle returns to the side after being sidelined with a groin injury for the first Test which Taylor also missed with a sore back contrary to earlier reports of a stiff shoulder.
Ramnaresh Sarwan, the West Indies captain for the first Test, felt the home team played well throughout the Test match.
"The bowlers bowled well especially in the second innings, and they gave the batters an opportunity to actually get a total that we could have batted and win the game, but unfortunately it didn't happen that way," he said.
"It's really good for us, and I hope we can keep it up and get better in second Test," he added.
West Indies came close to an upset victory, but then gave up the ghost on the final day after they were dismissed 96 runs short of their winning target.
West Indies (from): Chris Gayle (captain), Ramnaresh Sarwan (vice captain), Sulieman Benn, Dwayne Bravo, Shivnarine Chanderpaul, Fidel Edwards, Xavier Marshall, Runako Morton, Brenton Parchment, Daren Powell, Denesh Ramdin, Darren Sammy, Devon Smith, Jerome Taylor.
Australia (from): Ricky Ponting (captain), Michael Clarke (vice captain), Doug Bollinger, Beau Casson, Stuart Clark, Brad Haddin, Brad Hodge, Mike Hussey Phil Jaques, Mitchell Johnson, Simon Katich, Brett Lee, Stuart MacGill, Ashley Noffke, Andrew Symonds.