Derbyshire inflicted more misery on Worcestershire as Usman Khawaja's unbeaten 89 paved the way for a comfortable six-wicket victory at New Road.
The Pears, who have now lost six of seven matches in all competitions this season, could only amass 171 all out after batting first in front of their home fans.
Tim Groenewald was the pick of the Derbyshire attack with 4-22, while the hosts' main resistance came in the form of James Cameron's 80-ball 69.
Derbyshire measured their run chase to perfection, thanks in the main to Khawaja, who shared a fluent 84-run partnership with Chesney Hughes at the top of the order.
Young Anguillian Hughes made 42 before Worcestershire captain Daryl Mitchell trapped him lbw in the 19th over of the chase.
The dismissals of Wes Durston (6) and Greg Smith (14) threatened to derail Derbyshire, however Khawaja continued to find the rope to keep the visitors up with the rate.
The elegant left-hander found useful support from Wayne Madsen (21) down the order and the Falcons eased home with eight balls to spare to move two points clear at the top of Group A.