Worcestershire will be without veteran batsman Graeme Hick when they welcome Leicestershire to New Road.
The 41-year-old has decided to have a minor operation on his elbow to remove fragments of cartilage and will be out for two weeks.
Moeen Ali comes in to take Hick's place in the Worcestershire middle order.
Seamer Chris Whelan has also been included in a 12-man squad and may make his County Championship debut.
The former Middlesex player could be drafted in to replace Simon Jones, who bowled just three overs in the drawn game with Warwickshire last week due to a stiff neck.
James Taylor is set for his first-class debut after being included in Leicestershire's 12-man squad.
The 18-year-old, who was England Under 19's best batsman at the recent World Cup, has been given permission to leave his A Level studies at Shrewsbury School and link up with the Foxes.
Senior coach Tim Boon said: "James will be in the squad. We will look at the pitch on Wednesday morning and decide as to whether to play an extra batsman.
"He has earned the right to play. He has forced his way into the England Under 19s and was top scorer in the World Cup.
"What I want is for every young player to earn the right to come into the first team and he has done that."
South African fast bowler Garnett Kruger replaces Jermaine Lawson as Leicetershire look to build on last week's victory over Middlesex.