Jack Brooks made a good early impression for Yorkshire but Sussex are still in firm command after day two of the Division One fixture at Headingley.
Knocks of 92 from skipper Ed Joyce and 93 from wicketkeeper-batsman Ben Brown guided Sussex to a final total of 356, giving them a first innings lead of 260.
Having been bowled out for just 96 first time around, the Tykes suffered an early blow in their second innings when opener Alex Lees (four) was dismissed.
Adam Lyth (eight not out) and Phil Jaques, unbeaten on 15, saw Yorkshire to 27-1 by the time bad light halted play shortly before the tea interval. Rain followed soon after, meaning no further action was possible.
Sussex had begun Thursday's play on 104-3 and Rory Hamilton-Brown batted freely in reaching 26 in the morning session, only to then perish lbw to another new boy at Yorkshire, seamer Liam Plunkett.
The visitors then lost Joe Gatting (20) but Joyce - who had been unbeaten on four overnight - and Brown combined in a 120-run stand for the sixth wicket.
Neither man, however, managed to reach three figures; Joyce was caught at second slip by Lyth and then was quickly joined in the pavilion by Chris Jordan after he fell for a first-ball duck to Brooks (4-76).
The same bowler denied Brown a century too, knocking over his middle stump to end an fine 95-ball innings that saw 14 boundaries and one recorded six which included four overthrows.
Brooks also removed Steve Magoffin (11) before Ryan Sidebottom ended the innings by trapping former England team-mate Monty Panesar leg before, giving the experienced left-armer final figures of 4-72.