Lyon's alarming slump in form continued on Saturday as they lost 3-1 at home to Guingamp.
Juan Cuadrado scored the only goal of the game as 10-man Juventus beat Lyon 1-0 in the Champions League.
Paris Saint-Germain claimed a share of second place in Ligue 1 with a 2-1 win at Nancy.
Monaco defender Djibril Sidibe has revealed he rejected a move to Arsenal in the summer over concerns about making the first team.
Monaco thrashed 10-man Metz 7-0, while there were wins for Lille, Caen, Nantes and PSG in Ligue 1 on Saturday.
Miralem Pjanic scored one and set up another as Juventus beat Dinamo Zagreb 4-0 in the Champions League, while Monaco drew with Bayer Leverkusen.
Monaco moved to the top of Ligue 1 after coming from behind to beat Angers 2-1 while Lyon were upset by Lorient.
Mario Balotelli scored twice as Nice beat Monaco 4-0 to go top of Ligue 1, while there were also wins for Lyon and Bordeaux.
Thomas Lemar fired a late double as Monaco moved three points clear of PSG at the top of Ligue 1 with a 3-0 win against Rennes.
Tottenham's return to the Champions League ended in disappointment with a 2-1 defeat to Monaco at Wembley.
Catch up with action as Tottenham started their Champions League campaign with a 2-1 defeat to Monaco at Wembley.
Monaco midfielder Joao Moutinho has revealed he was "minutes" away from signing for Tottenham in August 2012.
Monaco returned to the top of the Ligue 1 table thanks to a thumping 4-1 win in Lille on Saturday.
Borussia Dortmund hit six, while Juventus were held by Sevilla on the second night of Champions League group stage action.
Manchester United and Chelsea have been accused of failing Radamel Falcao by Monaco vice-president Vadim Vasilyev.
Brazilian defender Fabinho has signed a two-year contract extension with Monaco until 2021, the club announced on Friday.
Tottenham will set a new record for the best-attended Champions League game in Great Britain when they face Monaco next week.
Ivan Cavaleiro has joined Wolves for a club record transfer fee, reported to be around £7m.
Monaco defender Fabinho is 'likely' to remain at the club this summer, a senior club source has told Sky Sports News HQ.
Paris Saint-Germain suffered their first league defeat since March as Monaco struck an early blow in the Ligue 1 title race.