Lyon secured a Champions League place for next season after thrashing Monaco 6-1 at Parc Olympique Lyonnais.
Monaco missed the chance to return to second place in Ligue 1 after conceding a late goal to draw 1-1 at Rennes.
Monaco beat out-of-form Marseille 2-1 at Stade Louis II to move back into second place above Lyon in Ligue 1.
Marseille lost more ground in their bid to play in Europe next season as a 1-1 draw at Lorient extended their winless run in Ligue 1 to six games.
Paris Saint-Germain fielded a second-string side and were held 0-0 at home by Montpellier in Ligue 1 on Saturday.
Zlatan Ibrahimovic scored twice as Paris Saint-Germain moved 27 points clear at the top of Ligue 1 thanks to a 4-1 demolition of Reims.
A much-changed Paris St-Germain saw their run of 16 consecutive wins ended following a 0-0 draw with Lille on Saturday.
Monaco beat Nice 1-0, despite going down to 10 men during the Ligue 1 clash on Saturday.
Crystal Palace are bottom of the Europe-wide form table - and only one Premier League team makes the top 10.
Angers closed the gap on second-place Monaco to two points after thrashing them 3-0 on Saturday.
Angel Di Maria scored twice as Paris Saint-Germain continued their dominance of Ligue 1 with a 5-1 home win over Angers.
PSG were grateful to Zlatan Ibrahimovic as his second-half goal secured a 1-0 win away to Toulouse in on Saturday.
Lille thumped Lorient 3-0 on Saturday to climb to 11th in the Ligue 1 table.
Montpellier have accepted Rolland Courbis' resignation and will reveal his successor on Sunday.
Montpellier striker Rodrigue Ninga scored twice as Marseille were held to a 2-2 draw in Ligue 1.
Ronny Rodelin snatched a late equaliser for Caen as they extended their unbeaten run to four games with a 1-1 draw at Monaco.
PSG extended their lead to 13 points at the top of Ligue 1 after winning 2-1 away at Lorient on Saturday.
Gazelec Ajaccio recorded their first-ever Ligue 1 victory on Saturday, while Montpellier beat Bastia to move out of the bottom three.
Hatem Ben Arfa scored twice, including a superb solo effort, as 10-man Nice ended St Etienne's five-match winning run.
Fabinho scored a controversial penalty in the fifth minute of stoppage time as Monaco came from 2-0 down to win 3-2 at Ligue 1 basement boys Montpellier.