Martin Johnson has brought Joe Worsley and Mike Tindall into England's starting XV to play Wales on Saturday.
Gloucester No.8 Luke Narraway believes a loss against Cardiff will end their hopes of a place in the Heineken Cup quarter-finals.
Gloucester maintained their pursuit of Cardiff Blues in Pool Six with a bonus-point victory over Calvisano.
Gloucester number eight Luke Narraway has signed a two-year contract extension keeping him at Kingsholm until 2010.
Paul Hodgson, Luke Narraway and Michael Lipman are to stay with England's training squad in the build-up to the Six Nations opener.
England and London Wasps are anxiously waiting news on the full extent of Paul Sackey's illness.

Latest Sky Sports News Report
Wigan v Fulham - 2nd Half
Wigan v Fulham - 1st Half
West Ham v Everton - 2nd Half
West Ham v Everton - 1st Half
UBS Hong Kong Open Preview
HSBC Champions Review
Haye is enjoying the moment
Chris Burton catches up with Sam Stockley on the day the experienced defender hangs up his boots.
Liverpool undid their hard work of last week, Chelsea marched on while Arsenal claimed the derby spoils.