The second part of our live Sunday double header is the 'Manning bowl', Peyton's Denver Broncos making the trip to take on his younger brother Eli's New York Giants.
The teams are coming off contrasting performances; Denver enjoyed a long week of preparation after demolishing defending Super Bowl champions Baltimore in the Thursday night season opener, while the Giants produced an error-strewn display in a 36-31 defeat on the road at division rivals Dallas.
Our NFL anchorman Kevin Cadle previews the game and makes his prediction.
Denver Broncos @ New York Giants - Sky Sports 2 HD from 9pm
You know how it is in families, the older brother usually beats up on the younger brother - and that's what has happened on the two previous occasions Peyton and Eli have played against each other in the NFL.
But I'm going to stick up for Eli as his supporting cast doesn't always do him many favours. That was shown again last week when the Giants turned the ball over six times at Dallas and still only lost by five points.
Starting running back David Wilson was benched by Giants head coach Tom Coughlin after giving up two early fumbles and his team-mates will have been messing around with him in the locker room and practice facility this week, trying to knock the ball out of his hands and making a joke of it.
But it is an issue that he needs to address quickly as Coughlin doesn't have a whole lot of choice at the position. They've re-signed Brandon Jacobs this week but he's not going to hurt you running ball.
The Broncos are the early Super Bowl favourites with the bookies and, fresh from his seven-touchdown display last week, Peyton is still playing as well as ever.
But, if we are talking about winning championships, I have two questions about this team.
First, is the defence consistent enough? It certainly looked up to the task against Baltimore and they still have Von Miller to return from suspension to give them a boost.
Second, can the running game carry their share of the load offensively? It doesn't matter to me that there is a committee in the backfield (Knowshon Moreno, Montee Ball and Ronnie Hillman split carries in week one) because none of these guys are stars, they are not comparable with the elite rushers in this league.
Kev's call: This is a tough one - and I'm trying not to base my prediction on just one week - but I think the Broncos have the better team and Peyton will come out on top once again.