Go Ahead Eagles can only strive for a play-off place in their unlikely bid to avoid relegation after they were beaten 3-2 by Groningen.
Ajax kept up the pressure on leaders Feyenoord in the race for the Eredivisie title by thrashing Heerenveen.
Steven Berghuis' double salvaged a point for Feyenoord as the Eredivisie leaders were held to a 2-2 at PEC Zwolle on Sunday.
PSV conceded a last-minute equaliser at FC Twente as their hopes of catching the Eredivisie's top two suffered a setback.
PSV Eindhoven moved up to second place in the Eredivisie after a 2-0 win at Sparta Rotterdam.
Feyenoord maintained their four-point lead at the top of the Eredivisie table with a comfortable 5-2 win over AZ Alkmaar.