Go Ahead Eagles can only strive for a play-off place in their unlikely bid to avoid relegation after they were beaten 3-2 by Groningen.
Ajax kept up the pressure on leaders Feyenoord in the race for the Eredivisie title by thrashing Heerenveen.
Steven Berghuis' double salvaged a point for Feyenoord as the Eredivisie leaders were held to a 2-2 at PEC Zwolle on Sunday.
PSV conceded a last-minute equaliser at FC Twente as their hopes of catching the Eredivisie's top two suffered a setback.
PSV Eindhoven moved up to second place in the Eredivisie after a 2-0 win at Sparta Rotterdam.
Feyenoord maintained their four-point lead at the top of the Eredivisie table with a comfortable 5-2 win over AZ Alkmaar.
PSV Eindhoven bounced back from the defeat by Eredivisie leaders Feyenoord to sweep past Roda JC 4-0 at Philips Stadion.
Feyenoord scored late to beat PSV Eindhoven 2-1 and maintain their five-point lead at the top of the Eredivisie.
Feyenoord won 2-0 at Twente on Sunday to maintain their five-point Eredivisie lead, as Ajax, PEC Zwolle and Utrecht also recorded victories.
Feyenoord retained their five-point lead at the top of the Eredivisie with a resounding 4-0 win over NEC Nijmegen.
Feyenoord extended their advantage at the top of the Eredivisie after beating Willem II 1-0 on Saturday.
Feyenoord consolidated their lead at the top of the Eredivisie with a 2-0 win away to struggling Roda, while Ajax beat Zwolle.
PSV had to settle for a point in their bid to close the gap on top two Feyenoord and Ajax after being held to a goalless draw at Roda JC.
PSV Eindhoven closed on the Eredivisie leaders with a 3-1 win over ADO Den Haag at Philips Stadion.
Ajax thumped NEC Nijmegen 5-0 as they tightened their grip on second place in the Eredivisie on Sunday.
PSV Eindhoven extended their unbeaten Eredivisie run to six games but were held to a 1-1 draw against FC Twente.
Feyenoord's lead at the top of the Eredivisie was cut to three points after a 2-2 draw at home to Heerenveen on Sunday.
Feyenoord grabbed a late winner to secure their perfect record and Ajax's winning run continued.
Davinson Sanchez and Kasper Dolberg both scored twice as Ajax beat Zwolle 5-1 while PSV won at Excelsior.
Eric Botteghin struck a late winner as Feyenoord maintained their perfect start to the Eredivisie season with a 1-0 win at PSV.