Lyon cruised through to the last 16 of the Europa League with a thumping 11-2 aggregate win over AZ Alkmaar.
Roma's Alessandro Florenzi has suffered a new injury that could rule him out for the rest of the season.
All you need to know about the Europa League last-16 draw, including when it takes place, and who Manchester United could face.
Edin Dzeko hit a 21-minute hat-trick as Roma took a 4-0 first-leg advantage in their Europa League last-32 tie against Villarreal.
Gonzalo Higuain scored twice as Juventus preserved their seven-point lead in Serie A with a 2-0 victory at 10-man Cagliari.
Edin Dzeko moved top of the Serie A scoring charts after netting twice in Roma's 4-0 win over Fiorentina on Tuesday.