Harlequins host the first of at least 40 live games from The European Champions Cup and Challenge Cup on Sky Sports.
European Challenge Cup holders Gloucester will face local rivals Worcester Warriors in the 2015-16 competition.
Gloucester will play their first play-off fixture at home as they chase a spot in next season's European Champions Cup.
Friday's European Challenge Cup final could be the game of the weekend, says Dewi Morris.
Jonny May says Gloucester 'did it for the city' when they beat Edinburgh 19-13 in the Challenge Cup final on Friday.
Greig Laidlaw says there will be no conflict of emotions when he runs out on Friday to face his former club Edinburgh.
Gloucester return to the scene of their 2006 Challenge Cup success in Friday's final against Edinburgh at the Stoop.
Billy Twelvetrees says victory in the European Challenge Cup final on Friday night will be "a huge bonus" for Gloucester.
Gloucester booked their place in the European Challenge Cup final with victory over Exeter at Kingsholm on Saturday.
Edinburgh advanced to their first European final after beating Dragons 45-16 in the European Challenge Cup semi-final.
West Country rivals Gloucester and Exeter Chiefs meet at Kingsholm in a crunch Challenge Cup semi-final on Saturday.
A place in the Challenge Cup final is on the line when Edinburgh and Newport Gwent Dragons meet at Murrayfield on Friday.
Stuart Barnes says Leinster desperately need a Champions Cup semi-final win at Toulon after another PRO12 defeat.
Edinburgh came out on top in a topsy-turvy European Challenge Cup quarter-final against London Irish.
London Irish head coach Glenn Delaney cut a frustrated figure after his side lost 23-18 to Edinburgh in the Challenge Cup.
Newport Gwent Dragons got the better of Welsh rivals Cardiff Blues to reach the semi-finals of the European Challenge Cup.
Rob Baxter praised Exeter's consistency as they beat Newcastle to reach the European Challenge Cup semi-finals.
Gloucester beat Connacht 14-7 to make it through to the European Challenge Cup semi-finals on Friday.
Newcastle, Exeter, London Irish, Cardiff and Connacht recorded bonus-point wins in the Challenge Cup.
London Irish recall winger Topsy Ojo in their only change for the European Challenge Cup quarter-final with Edinburgh.