Aviva Premiership: Saracens take on Harlequins in Saturday's big clash
Saracens will take on Harlequins with over 80,000 tickets sold ahead of Saturday's big clash at Wembley Stadium.
Last Updated: 22/03/14 9:03am
Meanwhile, table-topping Northampton Saints welcome back their Six Nations contingent for their game with Sale in Salford.
In the day's other games, London Irish host Bath while Gloucester face Newcastle at Kingsholm.
Saracens are without a win on their last three visits to Wembley although they have won their last three Aviva matches. They have named Owen Farrell and Mako Vunipola in their starting XV for the showdown.
Mark McCall welcomes back the duo from England duty along with full-back Alex Goode. Goode is joined by David Strettle and Chris Ashton in a strong Saracens back-three.
Fresh from his 22 point haul in Rome last weekend Farrell start the game at fly-half, with Richard Wigglesworth joining him in the halves.
Up front, Vunipola returns to the side at loosehead prop alongside Schalk Brits and James Johnston in the Saracens front row.
Meanwhile, Harlequins, who are four points off the pace in the race for the playoffs, have made six changes to the side that played Worcester Warriors. Joe Marler returns from international duty with England to start at loosehead.
Danny Care, Mike Brown and Chris Robshaw have been rested and will return against London Irish at The Stoop next Saturday.
Premiership leaders Northampton are the form team, although they lost in the LV=Cup Final to Exeter last weekend.
They're game against Sale in Salford will be the first of a double header, as the two sides will meet again on April 3 in the Amlin Challenge Cup quarter final.
Northampton make seven changes to the team from last Sunday, with all the club's half-dozen returning Six Nations internationals coming into the starting XV along with Stephen Myler, who was a late withdrawal in Exeter.
Luther Burrell returns at inside centre, where he partners James Wilson, and with George North coming onto the left wing Jamie Elliott switches to the right flank.
Samu Manoa's absence on international duty with the USA in Uruguay means that Courtney Lawes partners Christian Day in the second row, with GJ Van Velze continuing at number eight.
The game will be Sale Sharks' first at home since the narrow defeat to Saracens in mid-February. They will be determined to turn their opponents over and put themselves in the mix for a play-off spot.
Prop Henry Thomas is on the bench following his Six Nations commitments with England, while Danny Cipriani and Dwayne Peel are the half-backs.
Irish host Bath in the St Patrick's Party with a bumper crowd of over 20,000 expected to turn out at the Madejski Stadium.
London Irish duo Jamie Hagan and Fergus Mulchrone both return after injury in a team captained by lock George Skivington, while the back-three includes Marland Yarde and James O'Connor.
Bath show nine changes from the team that suffered an LV= Cup semi-final defeat against Exeter last time out. Among those back in action are England trio George Ford, David Wilson and Dave Attwood, while Wales prop Paul James is also back from international duty.
Veteran centre Mike Tindall will captain Gloucester as they host rivals Newcastle Falcons, who are looking to avoid an 11th defeat in a row, which would equal their worst run in the competition.
England players Ben Morgan and Jonny May will be on the Gloucester bench, but centre Billy Twelvetrees is given more time to recover from an infected knee. Mike Tindall captains a team that sees call-ups for wing Martyn Thomas and prop Shaun Knight.
Newcastle boss Dean Richards has made four changes, with England Under-20s wing Zach Kibrige gaining a start, replacing Lee Smith, while centre Danny Barnes returns. Oliver Tomaszczyk replaces suspended prop Kieran Brookes and number eight Chris York also features.