Keelan Giles added another pair of tries to his collection as Ospreys coasted to a 59-7 Challenge Cup win over Grenoble.
Tom Catterick makes his first appearance of the season when Newcastle Falcons visit Lyon in the Challenge Cup on Friday.
Zack Holmes kicked two late penalties to give La Rochelle a 25-19 win over Toulouse and move back into second place.
Jonny May made a try-scoring comeback to help Gloucester open their European Challenge Cup campaign with a 47-27 away win over Bayonne.
Ulster Rugby have signed Georgian tight-head prop Anton Peikrishvili in a bid to ease their front-row injury crisis.
Wasps have confirmed Italian international prop Lorenzo Cittadini is leaving the club to join Bayonne for next season.
Champions Cup holders Saracens have been drawn against Toulon while Bath will meet Bristol in the Challenge Cup.
Lionel Beauxis missed with the last kick of the game to cost Bordeaux-Begles a place in the Top 14 play-offs.
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