The Ospreys advanced to the European Challenge Cup quarter-finals with a 47-7 win over Lyon at the Liberty Stadium.
Manchester United have rejected a bid from Lyon for Memphis Depay.
Keelan Giles added another pair of tries to his collection as Ospreys coasted to a 59-7 Challenge Cup win over Grenoble.
Gloucester have signed back-row forward Carl Fearns from French Top 14 side Lyon ahead of the 2017/18 season.
Zack Holmes kicked two late penalties to give La Rochelle a 25-19 win over Toulouse and move back into second place.
Struggling Lyon will look to their Toulon old boys to stun the three-time European champions in Sunday's Top 14 clash.
Newcastle suffered an ignominious start to their Challenge Cup campaign as they fell to a 45-0 rout against the Ospreys.
Emmanuel Adebayor has refuted claims he asked for whisky and smoked cigarettes at a meeting as he tried to secure a contract with Lyon.
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