There are five Challenge Cup encounters on Saturday, including Edinburgh v Harlequins and Lyon v Ospreys.
Newcastle suffered an ignominious start to their Challenge Cup campaign as they fell to a 45-0 rout against the Ospreys.
A host of internationals are in action in the Challenge Cup on Friday, including Ospreys' Dan Biggar and Alun Wyn Jones.
Emmanuel Adebayor has refuted claims he asked for whisky and smoked cigarettes at a meeting as he tried to secure a contract with Lyon.
Champions Cup holders Saracens have been drawn against Toulon while Bath will meet Bristol in the Challenge Cup.
West Ham have had a £31m bid for Lyon striker Alexandre Lacazette rejected by the Ligue 1 side, Sky sources understand.
Newly-promoted Lyon have completed the signing of France fly-half Frederic Michalak ahead of their return to Top 14.
Team of the week includes strong semi-finalists and leaders of the pack from the Top 14 and Super Rugby.
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Barbarians v South Africa
5th November 2016