Mike Phillips starts for Sale against Leicester while Billy Twelvetrees will make his 100th start for Gloucester.
Sale Sharks boss Steve Diamond has described Leicester as "the Manchester United of Aviva Premiership rugby" prior to Saturday's meeting between the clubs.
Sale half-back Peter Stringer could miss three months of the Aviva Premiership campaign after tearing his biceps tendon.
Sale came back from trailing 31-17 to gain a late draw against Worcester in a nine-try thriller at Sixways.
Greig Laidlaw kicked 16 points as Gloucester secured their first victory of the season with a 26-13 triumph over Sale.
Sale Sharks boss Steve Diamond wants his players to establish some early-season momentum in the Aviva Premiership.
Harlequins back row Mat Luamanu has been banned for three weeks after appearing at an RFL disciplinary panel hearing.
Sale Sharks returned to winning ways with a 19-10 victory at home to Harlequins, who had Mat Luamanu sent off late on.
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