Cian Healy and Mike Ross return from injury for Leinster against Zebre while David Bulbring makes his Scarlets debut against Edinburgh.
Munster were forced to battle it out with Zebre as the Irish side came away with a 16-12 win in the PRO12 on Saturday.
Robbie Henshaw made a try-scoring return as Connacht secured a place in the European Challenge Cup quarter-finals.
Ireland centre Robbie Henshaw makes his return for injury in Connacht's must-win clash with Enisei.
Challenge Cup holders Gloucester booked their place in the knockout stages with a 20-10 triumph over La Rochelle.
Challenge Cup holders Gloucester can book their place in the knockout stages with victory over La Rochelle on Saturday.
Zebre climbed out of the bottom two of the Guinness PRO12 standings after seeing off Italian rivals Treviso 18-8.
Zebre will be looking for their third straight win of the season when they travel to Stadio Monigo to take on Treviso.
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Barbarians v South Africa
5th November 2016