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London Broncos pair Luke Dorn and Michael Robertson are out of Friday's clash with St Helens after it was confirmed the backs will miss the remainder of the season after undergoing surgery.
Full-back Dorn, who is out of contract at the end of the year, suffered a hip injury in last week's Super League clash against Leeds and may now have played his final game for the club.
Winger Robertson missed the 30-18 defeat by the Rhinos with an elbow injury.
To compound the problems, forward Scott Wheeldon faces a spell on the sidelines with a torn calf.
The injuries represent yet more bad news for the beleaguered Broncos, who are three points adrift at the foot of the table with just four games remaining, although coach Tony Rea remains positive.
He said: "It's not frustrating, it's the opposite. It gives a great opportunity for some other guys to come in. I can see the upside from it."
For Saints, Gareth O'Brien has been stepped down by the coaching staff after two high shots in recent weeks, with Joe Greenwood being recalled.
The fifth-placed hosts will be looking to cement their place in the play-offs with this clash, sitting five points ahead of ninth-placed Bradford Bulls and six points adrift of fourth-placed Leeds Rhinos.
St Helens Clough, Greenwood, Hohaia, Howarth, Jones, Laffranchi, Lomax, Makinson, McCarthy-Scarsbrook, Manu, Meli, Puletua, Richards, Swift, Turner, Walker, Walmsley, Wellens, Wilkin.
London Broncos: Bishay, Bryant, Colbon, Cook, Dollapi, Fisher, Howell, Hurst, Kaufusi, Krasniqi, Lee, Macani, McMeeken, Melling, Rodney, Sarginson, Soward, Wicks, Woodburn-Hall.
|Click here for more betting|
|9||Hull K R||10||9|
|11||Salford Red Devils||10||8|
|14||Bradford Bulls *||10||-2|
|Thursday 1st May|
|20:00||St Helens vs London Broncos|
|Friday 2nd May|
|20:00||Leeds vs Wigan|
|Saturday 3rd May|
|18:00||Catalan Dragons vs Salford|
|Sunday 4th May|
|15:00||Bradford vs Warrington|
|15:00||Hull K R vs Widnes|
|15:00||Huddersfield vs Castleford|
|15:00||Hull vs Wakefield|
|Thursday 8th May|
|20:00||Castleford vs Leeds|
|Friday 9th May|
|20:00||Widnes vs Wakefield|
|20:00||Warrington vs Catalan Dragons|
|Monday 21st April|
|Catalan Dragons 37 - 24 Hull K R|
|Castleford 40 - 6 Warrington|
|Wigan 84 - 6 Bradford|
|Huddersfield 36 - 16 Wakefield|
|Hull 40 - 4 London Broncos|
|Widnes 40 - 26 St Helens|
|Leeds 32 - 4 Salford|
|Friday 18th April|
|Salford 22 - 42 Huddersfield|
|Wakefield 20 - 43 Castleford|
|Warrington 44 - 6 Widnes|
Read the thoughts and opinions of Stevo with skysports.com