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Wigan and Warrington take centre stage on Friday night as two of Super League's heavyweights go toe-to-toe at the DW Stadium.
The Wolves did the regular-season double over the Cherry and Whites last season, including a 24-6 triumph on their travels last March.
However the Warriors did come out on top when the sides met in the Challenge Cup, ending the Wire's two-year reign in the competition with a 44-24 win in a thrilling quarter-final at the Halliwell Jones Stadium.
Wigan have no fresh injury concerns for their second successive home fixture following last Sunday's 42-30 victory over the London Broncos.
Head coach Shaun Wane has made just one alteration to his squad, Jack Hughes taking the place of fellow youngster Matty Russell.
Wigan half-back Brett Finch has indicated the Warriors will be aiming to put down a marker when they meet Warrington at the DW Stadium.
The winners of the clash of last year's top two finishing teams will leapfrog leaders Huddersfield, at least for 48 hours, and strike a psychological blow against one of their main title rivals.
"We missed a golden opportunity against Widnes a fortnight ago, when we let ourselves down there," said Finch.
"Even though it's early in the season and probably won't have a bearing on what happens at the end of season, it would be good for our confidence to get a win against a strong team like Warrington."
Warrington could well have Brett Hodgson available, with the full-back in contention to face the Warriors in front of the Sky Sports cameras.
Hodgson, the 2009 Man of Steel, has missed his side's last two games with a back injury but has been included by coach Tony Smith in his 19-man squad.
"Brett is in and around the squad," first-team assistant coach Richard Marshall said. "I don't think he could have played last week but he has trained this week with a view to playing."
The visitors expect Lee Briers to shake off a hip problem and take his place in the half-back positions, while Michael Monaghan could also feature as he continues his return to action after a short lay-off for surgery.
Monaghan featured in the 32-30 win over Wakefield last Sunday after missing the previous two games following operations on both knees.
Marshall added: "I don't think he was too impressed with his own performance - by his own admission - but Wakefield had a really good go at him.
"His lack of match fitness showed but he is coming back from a double knee operation and he is pleased he got on the field and hopefully he will be better for the run."
Garreth Carvell is a certain absentee after suffering a neck injury in the loss at Leeds, Warrington's only reverse so far in the 2012 campaign.
Wigan: S. Tomkins, Charnley, Goulding, Carmont, Richards, Finch, Leuluai, Prescott, McIlorum, Hansen, Hock, O'Loughlin, Lima, Farrell, Tuson, Lauaki, Flower, Hughes, Spencer.
Warrington: Atkins, Blythe, C. Bridge, Briers, Cooper, Dwyer, Grix, Hill, Hodgson, McCarthy, J. Monaghan, M. Monaghan, Morley, Myler, Riley, Waterhouse, Westwood, Williams, Wood.
|Click here for more betting|
|7||Hull K R||9||9|
|10||Salford Red Devils||9||8|
|14||Bradford Bulls *||9||-2|
|Monday 21st April|
|15:00||Wigan vs Bradford|
|15:00||Widnes vs St Helens|
|15:00||Huddersfield vs Wakefield|
|15:00||Hull vs London Broncos|
|15:00||Leeds vs Salford|
|15:30||Castleford vs Warrington|
|17:00||Catalan Dragons vs Hull K R|
|Thursday 1st May|
|20:00||St Helens vs London Broncos|
|Friday 2nd May|
|20:00||Leeds vs Wigan|
|Saturday 3rd May|
|18:00||Catalan Dragons vs Salford|
|Friday 18th April|
|Salford 22 - 42 Huddersfield|
|Wakefield 20 - 43 Castleford|
|Warrington 44 - 6 Widnes|
|St Helens 14 - 33 Wigan|
|Thursday 17th April|
|Hull K R 21 - 20 Hull|
|Bradford 6 - 46 Leeds|
|London Broncos 22 - 28 Catalan Dragons|
|Saturday 12th April|
|Catalan Dragons 42 - 20 Widnes|
|Friday 11th April|
|Warrington 12 - 25 Hull K R|
|Wigan 36 - 14 London Broncos|
Read the thoughts and opinions of Stevo with skysports.com