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Hull FC coach Peter Gentle has been forced into three changes for the Good Friday derby against neighbours Hull KR.
With an extending injury list now including props Eamon O'Carroll and Chris Green, Gentle will give a debut to new signing Jay Pitts.
And such is the crisis amongst the forwards that Lee Radford has been asked to come out of retirement to take on the old enemy.
Full-back Wade McKinnon has been included in the squad after being sidelined with a groin injury, while Kirk Yeaman takes the place of the injured Tony Martin.
Centre Yeaman was included last week after recovering from a foot operation but although he didn't feature in the game against Bradford is expected to start this time.
Hull KR boss Craig Sandercock could name his strongest side since taking over in charge after including both skipper Ben Galea and stand-off Blake Green.
Neither has played this season but are both likely to enjoy some game time at the KC.
Utility back Craig Hall is also poised to return with Jordan Cox, Liam Salter and Sam Latus all missing out this week.
"I wasn't aware of how big it is until I got here," Sandercock said of the rivalry between the sides. "But on my first day here someone mentioned it and I've been reminded about it every day since.
"So I'm under no illusions as to how big it is and what it means to the people of East Hull and the supporters of this great club.
"We can safely say it's the only game we want to win for our supporters more than ourselves. They're the ones who follow our football team and they deserve to have some success."
A total of 19,000 tickets have already been sold for the 215th match between the sides, which was switched from Craven Park due to development work taking place there.
Hull squad: Aspinwall, Bowden, T. Briscoe, Ellis, Horne, Houghton, Kent, Lynch, Manu, McKinnon, Nicklas, Pitts, Radford, Sharp, Seymour, Tickle, Turner, Whiting, Yeaman.
Hull KR: McDonnell, Hall, Galea, Clinton, Withers, Carlile, Watts, Wheeldon, Taylor, Lovegrove, J. Hodgson, Paea, Horne, Murrell, Dobson, D. Hodgson, Mika, Welham, Green.
|Click here for more betting|
|7||Hull K R||9||9|
|10||Salford Red Devils||9||8|
|14||Bradford Bulls *||9||-2|
|Monday 21st April|
|15:00||Wigan vs Bradford|
|15:00||Widnes vs St Helens|
|15:00||Huddersfield vs Wakefield|
|15:00||Hull vs London Broncos|
|15:00||Leeds vs Salford|
|15:30||Castleford vs Warrington|
|17:00||Catalan Dragons vs Hull K R|
|Thursday 1st May|
|20:00||St Helens vs London Broncos|
|Friday 2nd May|
|20:00||Leeds vs Wigan|
|Saturday 3rd May|
|18:00||Catalan Dragons vs Salford|
|Friday 18th April|
|Salford 22 - 42 Huddersfield|
|Wakefield 20 - 43 Castleford|
|Warrington 44 - 6 Widnes|
|St Helens 14 - 33 Wigan|
|Thursday 17th April|
|Hull K R 21 - 20 Hull|
|Bradford 6 - 46 Leeds|
|London Broncos 22 - 28 Catalan Dragons|
|Saturday 12th April|
|Catalan Dragons 42 - 20 Widnes|
|Friday 11th April|
|Warrington 12 - 25 Hull K R|
|Wigan 36 - 14 London Broncos|
Read the thoughts and opinions of Stevo with skysports.com