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At Langtree Park, Friday April 6, kick-off 2.45pm, live on Sky Sports 2 HD
James Roby will take over as captain of St Helens for the Lancashire derby after Paul Wellens failed to overturn a one-match ban.
Wellens' absence means Tommy Makinson is poised to start at full-back while Josh Jones will make his home debut after his first appearance at Warrington.
Prop forward Tony Puletua is back from injury but Gary Wheeler has been left out as he continues to recover from a knock picked up against Leeds.
Wigan are expected to call upon prop Gil Dudson for his debut and threequarter Anthony Gelling for his second start with Lee Mossop, Ben Flower and Liam Farrell (hip) ruled out.
Epalahame Lauaki misses the short trip as he serves the second of his two game suspension.
Brett Finch is set to captain the side after Sean O'Loughlin failed a fitness test on a knee injury that kept him out of last week's win against Salford.
"I played in a Leeds-Bradford derby but there is nothing compared to this," said coach Shaun Wane.
"I played in some great ones at Knowsley Road and Central Park in front of massive crowds.
"It's been bred in me since I was a kid. Wigan people say we can lose against anybody apart from this game. I don't want to go there and get beat by that team.
"There are a lot of local lads in the St Helens team and a lot of locals in my team. It has the makings of a great game.
"You don't need to get your players up for this. There is a lot of healthy dislike for St Helens.
"We need to make sure we defend tough and take that enthusiasm away. The team that wants it more will win the game."
St Helens squad: Wellens, Gardner, Shenton, Soliola, Meli, Hohaia, Lomax, Perry, Roby, McCarthy-Scarsbrook, Puletua, Wilkin, Flannery, Flanagan, Clough, Magennis, Dixon, Makinson, J. Jones.
Wigan squad: S. Tomkins, Charnley, Goulding, Carmont, Richards, Finch, Leuluai, Prescott, McIlorum, Hansen, Hock, Lima, Tuson, Dudson, Gelling, Mellor, Hughes, Spencer, L. Tomkins.
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First Utility Super League Table
|9||Hull K R||3||2|
|10||Salford Red Devils||3||2|
|First Utility Super League|
|Thursday 5th March|
|20:00||Hull FC vs Leeds Rhinos|
|Friday 6th March|
|20:00||Wakefield Wildcats vs St Helens|
|20:00||Huddersfield Giants vs Widnes Vikings|
|20:00||Castleford Tigers vs Wigan Warriors|
|Saturday 7th March|
|15:30||Catalans Dragons vs Salford Red Devils|
|Sunday 8th March|
|15:00||Warrington Wolves vs Hull K R|
|Thursday 12th March|
|20:00||Huddersfield vs Castleford|
|Friday 13th March|
|20:00||Warrington vs Leeds|
|20:00||Wigan vs Hull|
|20:00||Widnes Vikings vs St Helens|
|First Utility Super League|
|Sunday 1st March|
|Widnes Vikings 58 - 16 Wakefield Wildcats|
|Hull K R 22 - 20 Wigan Warriors|
|Saturday 28th February|
|Salford Red Devils 32 - 28 Hull FC|
|Catalans Dragons 38 - 18 Warrington Wolves|
|Friday 27th February|
|St Helens 21 - 14 Castleford Tigers|
|Thursday 26th February|
|Leeds Rhinos 28 - 24 Huddersfield Giants|
|Sunday 15th February|
|Wakefield 44 - 24 Hull K R|
|Saturday 14th February|
|Catalans Dragons 13 - 12 Castleford|
|Friday 13th February|
|Hull 6 - 7 Warrington|
|Leeds 38 - 6 Widnes|
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