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James Roby will take over as captain of St Helens for the Lancashire derby after Paul Wellens failed to overturn a one-match ban.
Wellens' absence means Tommy Makinson is poised to start at full-back while Josh Jones will make his home debut after his first appearance at Warrington.
Prop forward Tony Puletua is back from injury but Gary Wheeler has been left out as he continues to recover from a knock picked up against Leeds.
Wigan are expected to call upon prop Gil Dudson for his debut and threequarter Anthony Gelling for his second start with Lee Mossop, Ben Flower and Liam Farrell (hip) ruled out.
Epalahame Lauaki misses the short trip as he serves the second of his two game suspension.
Brett Finch is set to captain the side after Sean O'Loughlin failed a fitness test on a knee injury that kept him out of last week's win against Salford.
"I played in a Leeds-Bradford derby but there is nothing compared to this," said coach Shaun Wane.
"I played in some great ones at Knowsley Road and Central Park in front of massive crowds.
"It's been bred in me since I was a kid. Wigan people say we can lose against anybody apart from this game. I don't want to go there and get beat by that team.
"There are a lot of local lads in the St Helens team and a lot of locals in my team. It has the makings of a great game.
"You don't need to get your players up for this. There is a lot of healthy dislike for St Helens.
"We need to make sure we defend tough and take that enthusiasm away. The team that wants it more will win the game."
St Helens squad: Wellens, Gardner, Shenton, Soliola, Meli, Hohaia, Lomax, Perry, Roby, McCarthy-Scarsbrook, Puletua, Wilkin, Flannery, Flanagan, Clough, Magennis, Dixon, Makinson, J. Jones.
Wigan squad: S. Tomkins, Charnley, Goulding, Carmont, Richards, Finch, Leuluai, Prescott, McIlorum, Hansen, Hock, Lima, Tuson, Dudson, Gelling, Mellor, Hughes, Spencer, L. Tomkins.
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Super League Table
|9||Hull K R||27||23|
|10||Salford Red Devils||27||23|
|13||Bradford Bulls *||27||10|
|First Utility Super League|
|Thursday 5th February|
|20:00||Widnes vs Wigan|
|Friday 6th February|
|20:00||St Helens vs Catalans Dragons|
|Saturday 7th February|
|15:00||Warrington Wolves vs Salford Red Devils|
|Sunday 8th February|
|15:00||Huddersfield vs Hull|
|15:00||Hull K R vs Leeds|
|15:30||Castleford vs Wakefield|
|Thursday 12th February|
|20:00||Salford vs St Helens|
|Friday 13th February|
|20:00||Hull vs Warrington|
|20:00||Leeds vs Widnes|
|20:00||Wigan vs Huddersfield|
|First Utility Super League|
|Saturday 11th October|
|St Helens 14 - 6 Wigan|
|Friday 3rd October|
|Wigan 16 - 12 Warrington|
|Thursday 2nd October|
|St Helens 30 - 12 Catalans Dragons|
|Friday 26th September|
|Huddersfield 16 - 18 Catalans Dragons|
|Thursday 25th September|
|Castleford 14 - 30 Warrington|
|Saturday 20th September|
|Leeds 20 - 24 Catalans Dragons|
|Warrington 22 - 19 Widnes|
|Friday 19th September|
|St Helens 41 - 0 Castleford|
|Thursday 18th September|
|Wigan 57 - 4 Huddersfield|
|Sunday 14th September|
|Wakefield 18 - 42 Hull K R|
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