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Hull KR are still without stand-off Blake Green and forwards Joel Clinton and Scott Murrell as they bid to keep their play-off hopes alive against the leaders.
Centre Jake Webster returns and Josh Hodgson, Graeme Horne and Liam Salter have all shaken off injuries picked up in the home defeat by Wakefield a fortnight ago.
Wigan scrum-half Thomas Leuluai is poised to make his comeback from the broken leg he suffered playing for the Exiles, probably from the bench, as the Warriors seek the win that would secure them the league leaders' shield.
Wigan head coach Shaun Wane told the club's website: "We have done a lot of work in preparation for winning this game. It is really, really important. We want top spot and that league leaders' shield. It is in our control.
"If we win the game we will get it. It would be great to do that and the week after we play St Helens at home and we can get it presented then.
"I want it done and dusted this weekend. We have got a lot of players coming back so the competition for places is the best it's been for quite a few months.
"But if we don't turn up and don't concentrate we will be under the pump and in with a chance of losing the game."
Hull KR squad: Salter, Cox, Lovegrove, Horne, Netherton, O'Hara, Mika, Galea, Webster, J Hodgson, Paea, Sheriff, Hall, Dobson, Latus, Peterson, Withers, Taylor, D Hodgson.
Wigan squad: Carmont, Charnley, Farrell, Finch, Flower, Goulding, Hansen, Hock, Hughes, Lauaki, Lima, Leuluai, McIlorum, Mossop, O'Loughlin, Powell, Richards, Smith, S Tomkins.
|Click here for more betting|
|6||Hull K R||0||0|
|9||Salford City Reds||0||0|
|Friday 7th February|
|20:00||Wigan vs Huddersfield|
|Thursday 13th February|
|20:00||Warrington vs St Helens|
|Friday 14th February|
|20:00||Hull vs Catalan Dragons|
|Sunday 16th February|
|15:00||Hull K R vs Leeds|
|15:00||Widnes vs London Broncos|
|15:00||Bradford vs Castleford|
|15:00||Salford vs Wakefield|
|Thursday 20th February|
|20:00||Wakefield vs Bradford|
|Friday 21st February|
|20:00||Leeds vs Warrington|
|20:00||St Helens vs Hull|
|Saturday 5th October|
|Warrington 16 - 30 Wigan|
|Friday 27th September|
|Wigan 22 - 12 Leeds|
|Thursday 26th September|
|Warrington 30 - 22 Huddersfield|
|Friday 20th September|
|Leeds 11 - 10 St Helens|
|Thursday 19th September|
|Huddersfield 76 - 18 Hull|
|Saturday 14th September|
|Warrington 40 - 20 Leeds|
|St Helens 46 - 10 Hull K R|
|Friday 13th September|
|Hull 14 - 4 Catalan Dragons|
|Thursday 12th September|
|Huddersfield 8 - 22 Wigan|
|Sunday 8th September|
|Wakefield 36 - 32 Castleford|
Read the thoughts and opinions of Stevo with skysports.com