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St Helens will be boosted by the return of James Roby, Ade Gardner and Louie McCarthy-Scarsbrook for the visit of Leeds on Sunday.
All three have recovered from injuries and are named in caretaker coach Mike Rush's squad as he takes charge for the first time since Royce Simmons' dismissal.
Jonny Lomax has shaken off a knock but Sia Soliola is still sidelined with a knee problem.
Saints have not won in five matches - their worst run in the Super League era - and Rush and Keiron Cunningham have been given the task of getting their season back on track.
Captain Paul Wellens insists the club can turn their season around as they seek revenge for last year's Grand Final defeat at the hands of Leeds.
Wellens admits their wretched run has taken its toll. "Confidence is always an issue when you lose big games," he said. "I think when you lose confidence, players become anxious, snatching at passes and trying to rush things. That's probably what's happened to us.
"We've got to use this change as a clean slate, we have to ultimately start our season again.
"We'll continue to work hard. I'm just trying to encourage the boys to stay confident and back our own ability.
"I've no doubt that this squad can be successful this year. I think we can compete for the Challenge Cup and I think we can win the Grand Final. I've got that belief and I'm sure the rest of the guys have too."
Leeds coach Brian McDermott says his side are determined not to become distracted by the upheaval among their opponents.
"It was always going to be a big game but their run of results and the change of coach will probably add a bit of extra spice," he said.
"We haven't talked too much about what reaction there might be from the St Helens players. We will prepare for their best performance and know that we need to match it."
The Rhinos will give a debut to 18-year-old stand-off Stevie Ward. "Stevie is an exciting young local talent," said McDermott. "He has worked his way through our academy ranks and has consistently been outstanding in the Under 20s game so far this season. He deserves his shot in the first team.
"He is also a very grounded young man who is always keen to learn from those around him.
"I am sure he will benefit from the experience of being involved this week and take the step up to Super League in his stride."
Winger Lee Smith is also included for only the third time this season but Leeds have been dealt a late blow with the loss of influential half-back Danny McGuire.
The England international picked up a hamstring in training and is set to be sidelined for a fortnight, meaning he's likely to make his return during the busy Easter period.
McDermott said: "Danny suffered the injury in the week and tests have confirmed it will need to be rested."
Paul McShane, who was initially left out of the 19-man squad, is drafted in. Rob Burrow may be asked to switch back to scrum-half from hooker in the absence of McGuire.
St Helens squad: Wellens, Gardner, Shenton, Meli, Hohaia, Lomax, Perry, Roby, McCarthy-Scarsbrook, Puletua, Wilkin, Flannery, Laffranchi, Flanagan, Clough, Wheeler, Magennis, Dixon, Makinson.
Leeds squad: Webb, Jones-Bishop, Watkins, Hardaker, Hall, McShane, Burrow, Leuluai, Peacock, Ablett, Sinfield, Smith, Delaney, Kirke, Clarkson, Griffin, Moore, Hood, Ward.
|Click here for more betting|
|7||Hull K R||9||9|
|10||Salford Red Devils||9||8|
|14||Bradford Bulls *||9||-2|
|Monday 21st April|
|15:00||Wigan vs Bradford|
|15:00||Widnes vs St Helens|
|15:00||Huddersfield vs Wakefield|
|15:00||Hull vs London Broncos|
|15:00||Leeds vs Salford|
|15:30||Castleford vs Warrington|
|17:00||Catalan Dragons vs Hull K R|
|Thursday 1st May|
|20:00||St Helens vs London Broncos|
|Friday 2nd May|
|20:00||Leeds vs Wigan|
|Saturday 3rd May|
|18:00||Catalan Dragons vs Salford|
|Friday 18th April|
|Salford 22 - 42 Huddersfield|
|Wakefield 20 - 43 Castleford|
|Warrington 44 - 6 Widnes|
|St Helens 14 - 33 Wigan|
|Thursday 17th April|
|Hull K R 21 - 20 Hull|
|Bradford 6 - 46 Leeds|
|London Broncos 22 - 28 Catalan Dragons|
|Saturday 12th April|
|Catalan Dragons 42 - 20 Widnes|
|Friday 11th April|
|Warrington 12 - 25 Hull K R|
|Wigan 36 - 14 London Broncos|
Read the thoughts and opinions of Stevo with skysports.com