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Warrington head coach Tony Smith has named an unchanged 19-man squad for the visit of the reigning Super League champions.
It will be the Wolves' first home game in a month after four consecutive away fixtures, including the Magic Weekend in Manchester.
The game will also see the Wolves players step out onto the field wearing their charity shirts in aid of the Motor Neurone Disease Association.
Smith's men will be looking to get their title chase back on track after the 23-22 defeat to Hull KR last week.
Rhinos come into the game on the back of a 50-6 thumping from Wigan, but Wolves skipper Adrian Morley is reading little into that and has warned his team-mates to be on their guard.
"I thought Leeds had an off day and Wigan were showing that they are on fire at the moment," he said.
"I think Leeds got a bit shellshocked and when that happens against a side with so much momentum you can see big scores racked up.
"That was a harsh lesson for them, because no one wants to be beaten like that at any ground, let alone at home.
"They will have done a lot of hard work this week and a lot of soul searching and they will want a big performance against us."
Leeds will be without stand-off Danny McGuire after he picked up a groin injury in last week's 50-6 defeat to Wigan.
Stevie Ward, 19, has been drafted as cover while coach Brian McDermott has also opted to call up Ben Jones-Bishop and Darrell Griffin.
Prop Richard Moore sits this one out with Ian Kirke added to the 19.
"It was tough last week against a white-hot Wigan side and we did not help ourselves at times," said coach Brian McDermott.
"However, we have looked at that game early in the week and our focus has been on Warrington since then. We have a determined group of people who have been through some tough times together in the past.
"I have no doubt they will stick together, but Warrington present us with an immediate challenge to get ourselves back up to the level of performance we know we are capable of.
"We are without Danny so that is an enforced change, however we will make a couple of others as well.
"Stevie Ward will be involved. He played a couple of games earlier in the season and the time is right to give him another opportunity as he is an exciting player from our academy."
Rhinos are looking for an unlikely double after coming out on top 26-18 at Headingley earlier this year.
Warrington squad: Atkins, Blythe, C. Bridge, Briers, Carvell, Cooper, Grix, Harrison, Higham, Hill, Hodgson, McCarthy, J. Monaghan, Morley, O'Brien, Ratchford, Riley, Waterhouse, Westwood.
Leeds squad: Webb, Jones-Bishop, Hardaker, Hall, Burrow, Leuluai, Peacock, Jones-Buchanan, Ablett, Sinfield, L. Smith, Delaney, Bailey, Kirke, Clarkson, Hauraki, Griffin, Ward, Lunt.
|Click here for more betting|
|7||Hull K R||9||9|
|10||Salford Red Devils||9||8|
|14||Bradford Bulls *||9||-2|
|Monday 21st April|
|15:00||Wigan vs Bradford|
|15:00||Widnes vs St Helens|
|15:00||Huddersfield vs Wakefield|
|15:00||Hull vs London Broncos|
|15:00||Leeds vs Salford|
|15:30||Castleford vs Warrington|
|17:00||Catalan Dragons vs Hull K R|
|Thursday 1st May|
|20:00||St Helens vs London Broncos|
|Friday 2nd May|
|20:00||Leeds vs Wigan|
|Saturday 3rd May|
|18:00||Catalan Dragons vs Salford|
|Friday 18th April|
|Salford 22 - 42 Huddersfield|
|Wakefield 20 - 43 Castleford|
|Warrington 44 - 6 Widnes|
|St Helens 14 - 33 Wigan|
|Thursday 17th April|
|Hull K R 21 - 20 Hull|
|Bradford 6 - 46 Leeds|
|London Broncos 22 - 28 Catalan Dragons|
|Saturday 12th April|
|Catalan Dragons 42 - 20 Widnes|
|Friday 11th April|
|Warrington 12 - 25 Hull K R|
|Wigan 36 - 14 London Broncos|
Read the thoughts and opinions of Stevo with skysports.com