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London Broncos pair Luke Dorn and Michael Robertson are out of Friday's clash with St Helens after it was confirmed the backs will miss the remainder of the season after undergoing surgery.
Full-back Dorn, who is out of contract at the end of the year, suffered a hip injury in last week's Super League clash against Leeds and may now have played his final game for the club.
Winger Robertson missed the 30-18 defeat by the Rhinos with an elbow injury.
To compound the problems, forward Scott Wheeldon faces a spell on the sidelines with a torn calf.
The injuries represent yet more bad news for the beleaguered Broncos, who are three points adrift at the foot of the table with just four games remaining, although coach Tony Rea remains positive.
He said: "It's not frustrating, it's the opposite. It gives a great opportunity for some other guys to come in. I can see the upside from it."
For Saints, Gareth O'Brien has been stepped down by the coaching staff after two high shots in recent weeks, with Joe Greenwood being recalled.
The fifth-placed hosts will be looking to cement their place in the play-offs with this clash, sitting five points ahead of ninth-placed Bradford Bulls and six points adrift of fourth-placed Leeds Rhinos.
St Helens Clough, Greenwood, Hohaia, Howarth, Jones, Laffranchi, Lomax, Makinson, McCarthy-Scarsbrook, Manu, Meli, Puletua, Richards, Swift, Turner, Walker, Walmsley, Wellens, Wilkin.
London Broncos: Bishay, Bryant, Colbon, Cook, Dollapi, Fisher, Howell, Hurst, Kaufusi, Krasniqi, Lee, Macani, McMeeken, Melling, Rodney, Sarginson, Soward, Wicks, Woodburn-Hall.
|Click here for more betting|
|6||Hull K R||9||9|
|9||Salford Red Devils||8||8|
|14||Bradford Bulls *||9||-2|
|Friday 18th April|
|12:15||St Helens vs Wigan|
|14:45||Warrington vs Widnes|
|15:00||Wakefield vs Castleford|
|18:00||Salford vs Huddersfield|
|Monday 21st April|
|15:00||Wigan vs Bradford|
|15:00||Widnes vs St Helens|
|15:00||Huddersfield vs Wakefield|
|15:00||Hull vs London Broncos|
|15:00||Leeds vs Salford|
|15:30||Castleford vs Warrington|
|Thursday 17th April|
|Hull K R 21 - 20 Hull|
|London Broncos 22 - 28 Catalan Dragons|
|Bradford 6 - 46 Leeds|
|Saturday 12th April|
|Catalan Dragons 42 - 20 Widnes|
|Friday 11th April|
|Warrington 12 - 25 Hull K R|
|Wigan 36 - 14 London Broncos|
|Leeds 42 - 6 Wakefield|
|Bradford 24 - 38 Salford|
|Castleford 28 - 30 St Helens|
|Thursday 10th April|
|Hull 30 - 6 Huddersfield|
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