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Connacht welcome back Denis Buckley to their front row for the RaboDirect PRO12 clash with bottom club Aironi.
Buckley replaces the injured Brett Wilkinson in the only change to the side that beat Ulster last time out.
"We're looking for a strong performance and to finish the season on a high," said head coach Eric Elwood.
"We've had some excellent results in recent weeks and we hope to build on that and finish on an up. It'll be a big day for the likes of Ray (Ofisa) and Henry (Fa'afili) playing in front of the home crowd for the last time so it would be great to give them the send-off they deserve and finish with a win."
Aironi head to Galway for their last-ever away match in the competition with just one change to their starting XV
Giovanbattista Venditti returns on the wing, with Sinoti Sinoti moving to outside centre in place of the benched Gilberto Pavan.
Also among the replacements, Paolo Buso returns from a long injury break.
Connacht: 15 Gavin Duffy (c), 14 Tiernan O'Halloran, 13 Kyle Tonetti, 12 Henry Fa'afili, 11 Fetu'u Vainikolo, 10 Miah Nikora, 9 Frank Murphy, 8 George Naoupu, 7 Ray Ofisa, 6 John Muldoon, 5 Mike McCarthy, 4 Michael Swift, 3 Ronan Loughney, 2 Ethienne Reynecke, 1 Denis Buckley.
Replacements: 16 Adrian Flavin, 17 Stewart Maguire, 18 Rodney Ah You, 19 Mick Kearney, 20 Johnny O'Connor, 21 Paul O'Donohoe,. 22 Matthew Jarvis, 23 Eoin Griffin.
Aironi: 15 Tito Tebaldi, 14 Giulio Toniolatti, 13 Sinoti Sinoti, 12 Matteo Pratichetti, 11 Giovanbattista Venditti, 10 Luciano Orquera, 9 Tyson Keats, 8 Josh Sole, 7 Simone Favaro, 6 Nicola Cattina; 5 Marco Bortolami (cap), 4 Quintin Geldenhuys; 3 Lorenzo Romano, 2 Fabio Ongaro, 1 Matias Aguero.
Replacements: 16 Tommaso D'Apice, 17 Alberto De Marchi, 18 Luca Redolfini, 19 Joshua Furno, 20 Nick Williams, 21 Naas Olivier, 22 Gilberto Pavan, 23 Paolo Buso.
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|Saturday 25th May|
|16:45||Ulster vs Leinster|
|Saturday 11th May|
|Leinster 17 - 15 Glasgow|
|Friday 10th May|
|Ulster 28 - 17 Scarlets|
|Friday 3rd May|
|Edinburgh 31 - 24 Newport Gwent D'gons|
|Connacht 3 - 20 Glasgow|
|Zebre 25 - 27 Munster|
|Scarlets 17 - 41 Benetton Treviso|
|Leinster 37 - 19 Ospreys|
|Ulster 37 - 13 Cardiff Blues|
|Friday 26th April|
|Benetton Treviso 23 - 23 Connacht|
|Sunday 21st April|
|Zebre 22 - 41 Leinster|
|Saturday 20th April|
|Scarlets 24 - 6 Cardiff Blues|
|Friday 19th April|
|Connacht 18 - 34 Ulster|
|Glasgow 35 - 17 Ospreys|
|Benetton Treviso 30 - 10 Edinburgh|
|Newport Gwent D'gons 30 - 24 Munster|
|Saturday 13th April|
|Ospreys 28 - 3 Benetton Treviso|
|Munster 16 - 22 Leinster|
|Cardiff Blues 28 - 13 Zebre|
|Friday 12th April|
|Edinburgh 24 - 32 Connacht|
|Ulster 31 - 5 Newport Gwent D'gons|
|Scarlets 29 - 6 Glasgow|
Read the thoughts and opinions of Stuart Barnes with skysports.com