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The Ospreys will look to gain momentum for the Pro12 play-offs when they travel to Aironi on the final day of the regular season.
The Welsh side have never lost to an Italian team and go into the contest full of confidence having won three of their last four away matches.
Aironi have won just once since January and are bottom of the table with four wins all season from 21 outings.
Fit-again Paolo Buso is back in Aironi's starting XV for the first time in over a year.
Sinoti Sinoti and Giovanbattista Venditti are the wings, while Gabriel Pizarro returns to pair with Matteo Pratichetti at centres.
In the halves Naas Olivier is at 10 with Tito Tebaldi, who holds the record for most appearances in the club's short history, back at scrum half.
In the back row Nick Williams, after starting amongst the replacements is the last two games, returns at number 8 replacing Josh Sole. Simone Favaro and Nicola Cattina are the flankers.
No changes in the second row, with Quintin Geldenhuys and skipper Marco Bortolami. In the front row also hooker Roberto Santamaria returns from an injury suffered in the win against Munster. Matias Aguero and Lorenzo Romano are the props.
Ospreys are without a host of players, but still have a strong-looking side available for selection.
Justin Tipuric (back), Aaron Jarvis (hamstring), Tommy Bowe (haematoma), Kristian Phillips (abdomen) and Huw Bennett (Achilles) are all ruled out through injury.
Coach Steve Tandy is keen for to his charges to avoid any complacency in Italy.
"It's important that we keep the momentum of the last couple of months going and we'll expect the team to maintain the standards that they've set in the last few games," commented Tandy.
"It's easy for players to get distracted with a semi-final on the horizon, but the group has worked very hard this week and we've ensured that the focus has been firmly on Aironi and what will be a very difficult evening for us.
"The attitude of the team has been spot on over the last couple of months and they've got their reward for that with a home semi-final."
Aironi: 15 Paolo Buso, 14 Sinoti Sinoti, 13 Matteo Pratichetti, 12 Gabriel Pizarro, 11 Giovanbattista Venditti, 10 Naas Olivier, 9 Tito Tebaldi, 8 Nick Williams, 7 Simone Favaro, 6 Nicola Cattina; 5 Marco Bortolami (cap), 4 Quintin Geldenhuys; 3 Lorenzo Romano, 2 Roberto Santamaria, 1 Matias Aguero.
Replacements: 16 Fabio Ongaro, 17 Alberto De Marchi, 18 Salvatore Perugini, 19 Carlo Del Fava, 20 Josh Sole, 21 Tyson Keats, 22 Luciano Orquera, 23 Gilberto Pavan.
Ospreys: 15 Richard Fussell, 14 Hanno Dirksen, 13 Andrew Bishop, 12 Ashley Beck, 11 Eli Walker, 10 Dan Biggar, 9 Kahn Fotuali'i, 8 Joe Bearman, 7 Sam Lewis, 6 Tom Smith, 5 Ian Evans, 4 Alun Wyn Jones (Capt), 3 Adam Jones 2 Richard Hibbard, 1 Paul James.
Replacements: 16 Scott Baldwin, 17 Ryan Bevington, 18 Joe Rees, 19 James King, 20 George Stowers, 21 Rhys Webb, 22 Matthew Morgan, 23 Tom Isaacs.
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|Friday 14th March|
|19:05||Ulster vs Scarlets|
|Friday 21st March|
|19:05||Ospreys vs Cardiff Blues|
|19:15||Leinster vs Zebre|
|19:45||Edinburgh vs Ulster|
|Saturday 22nd March|
|15:00||Glasgow vs Scarlets|
|19:15||Munster vs Benetton Treviso|
|Sunday 23rd March|
|15:05||Newport Gwent D'gons vs Connacht|
|Saturday 29th March|
|15:00||Zebre vs Newport Gwent D'gons|
|18:00||Benetton Treviso vs Edinburgh|
|18:30||Cardiff Blues vs Ulster|
|19:00||Leinster vs Munster|
|Sunday 30th March|
|14:05||Scarlets vs Connacht|
|Thursday 3rd April|
|18:30||Newport Gwent D'gons vs Edinburgh|
|Friday 11th April|
|19:05||Ulster vs Connacht|
|19:05||Ospreys vs Leinster|
|19:45||Edinburgh vs Cardiff Blues|
|Saturday 12th April|
|18:00||Benetton Treviso vs Newport Gwent D'gons|
|18:30||Munster vs Glasgow|
|18:30||Scarlets vs Zebre|
|Saturday 19th April|
|15:00||Zebre vs Edinburgh|
|15:00||Glasgow vs Ulster|
|15:00||Leinster vs Benetton Treviso|
|15:00||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
|Friday 28th February|
|Edinburgh 31 - 25 Ospreys|
|Ulster 38 - 8 Newport Gwent D'gons|
|Sunday 23rd February|
|Zebre 19 - 27 Connacht|
|Ospreys 11 - 25 Munster|
|Newport Gwent D'gons 24 - 23 Glasgow|
|Benetton Treviso 12 - 14 Ulster|
|Saturday 22nd February|
|Scarlets 25 - 21 Edinburgh|
|Thursday 20th February|
|Cardiff Blues 22 - 34 Leinster|
|Sunday 16th February|
|Ospreys 75 - 7 Benetton Treviso|
|Saturday 15th February|
|Munster 36 - 8 Zebre|
|Cardiff Blues 20 - 27 Glasgow|
|Connacht 11 - 7 Edinburgh|
|Friday 14th February|
|Leinster 31 - 19 Newport Gwent D'gons|
|Sunday 9th February|
|Zebre 8 - 31 Leinster|
|Glasgow 8 - 6 Connacht|
|Saturday 8th February|
|Munster 54 - 13 Cardiff Blues|
|Benetton Treviso 33 - 41 Scarlets|
|Friday 7th February|
|Ulster 10 - 7 Ospreys|
Read the thoughts and opinions of Stuart Barnes with skysports.com