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The Sharks will be targeting the win they need to stand a chance of clinching one of the final play-off spots when they take on the Cheetahs.
The Hurricanes, who beat the Chiefs on Friday, the Reds, the Bulls and the Crusaders are also in the mix for the three remaining play-off places - meaning that all the Sharks can do is win and then hope other results go their way.
The Sharks have been buoyed by news that Pat Lambie, Willem Alberts and Jacques Botes have all passed late fitness tests to take their place in the starting XV.
Lambie will replace Louis Ludik, who drops to the bench alongside Alberts and Botes, while there is also a start for Jandre Marais in the second row.
The Cheetahs will hand South Africa Sevens star Johannes Prinsloo his first Super Rugby cap.
Prinsloo replaces the injured Justin Downey at No.8, while Philip Snyman comes in on the wing and Jacques Coetzee starts on the bench.
Sharks: 15 Patrick Lambie, 14 JP Pietersen, 13 Tim Whitehead, 12 Francois Steyn, 11 Lwazi Mvovo, 10 Frederic Michalak, 9 Charl McLeod, 8 Ryan Kankowski, 7 Marcell Coetzee, 6 Keegan Daniel (capt), 5 Anton Bresler, 4 Jandre Marais, 3 Jannie du Plessis, 2 Craig Burden, 1 Tendai Mtawarira.
Replacements: 16 Bismarck du Plessis, 17 Wiehahn Herbst, 18 Pieter-Steph du Toit/Jean Deysel, 19 Willem Alberts, 20 Jacques Botes, 21 Meyer Bosman/Paul Jordaan, 22 Louis Ludik.
Cheetahs: 15 Willie le Roux, 14 Nico Scheepers, 13 Robert Ebersohn, 12 Barry Geel, 11 Philip Snyman, 10 Riaan Smit, 9 Piet van Zyl, 8 Boom Prinsloo, 7 Pieter Labuschagne, 6 Heinrich Brüssow, 5 Izak van der Westhuizen, 4 Andries Ferreira, 3 WP Nel, 2 Adriaan Strauss (captain), 1 Trevor Nyakane.
Replacements: 16 Hercu Liebenberg, 17 Marcel van der Merwe, 18 Waltie Vermeulen, 19 Ashley Johnson, 20 Jacques Coetzee, 21 Sias Ebersohn, 22 Andries Strauss.
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|Friday 24th May|
|08:35||Chiefs vs Crusaders|
|10:40||Melbourne Rebels vs Waratahs|
|Saturday 25th May|
|08:35||Blues vs Brumbies|
|10:40||Western Force vs Highlanders|
|14:00||Southern Kings vs Cheetahs|
|16:05||Stormers vs Reds|
|18:10||Sharks vs Bulls|
|Friday 31st May|
|08:35||Crusaders vs Waratahs|
|10:40||Brumbies vs Hurricanes|
|Saturday 1st June|
|08:35||Highlanders vs Blues|
|10:40||Reds vs Melbourne Rebels|
|16:05||Stormers vs Southern Kings|
|18:10||Cheetahs vs Bulls|
|Friday 7th June|
|10:40||Brumbies vs Melbourne Rebels|
|Sunday 9th June|
|07:05||Western Force vs Waratahs|
|Friday 28th June|
|08:35||Chiefs vs Hurricanes|
|Saturday 29th June|
|08:35||Highlanders vs Crusaders|
|14:00||Sharks vs Blues|
|16:05||Bulls vs Southern Kings|
|18:10||Stormers vs Cheetahs|
|Friday 5th July|
|08:35||Crusaders vs Chiefs|
|Saturday 6th July|
|08:35||Hurricanes vs Highlanders|
|14:00||Cheetahs vs Blues|
|16:05||Southern Kings vs Stormers|
|18:10||Bulls vs Sharks|
|Saturday 18th May|
|Cheetahs 27 - 13 Reds|
|Bulls 35 - 18 Highlanders|
|Waratahs 28 - 22 Brumbies|
|Crusaders 23 - 3 Blues|
|Friday 17th May|
|Western Force 13 - 23 Sharks|
|Melbourne Rebels 30 - 21 Stormers|
|Hurricanes 12 - 17 Chiefs|
|Saturday 11th May|
|Southern Kings 34 - 27 Highlanders|
|Waratahs 21 - 15 Stormers|
|Blues 36 - 32 Melbourne Rebels|
|Friday 10th May|
|Cheetahs 34 - 39 Hurricanes|
|Reds 32 - 17 Sharks|
|Chiefs 22 - 21 Western Force|
|Sunday 5th May|
|Brumbies 23 - 30 Crusaders|
|Saturday 4th May|
|Bulls 48 - 14 Hurricanes|
|Southern Kings 10 - 72 Waratahs|
|Western Force 11 - 11 Reds|
|Highlanders 25 - 22 Sharks|
|Friday 3rd May|
|Melbourne Rebels 33 - 39 Chiefs|
|Blues 18 - 17 Stormers|
|Sunday 28th April|
|Crusaders 30 - 26 Melbourne Rebels|
|Saturday 27th April|
|Cheetahs 26 - 12 Southern Kings|
|Bulls 30 - 19 Waratahs|
|Brumbies 41 - 7 Western Force|
|Chiefs 37 - 29 Sharks|
Read the thoughts and opinions of Stuart Barnes with skysports.com