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The Sharks will be targeting the win they need to stand a chance of clinching one of the final play-off spots when they take on the Cheetahs.
The Hurricanes, who beat the Chiefs on Friday, the Reds, the Bulls and the Crusaders are also in the mix for the three remaining play-off places - meaning that all the Sharks can do is win and then hope other results go their way.
The Sharks have been buoyed by news that Pat Lambie, Willem Alberts and Jacques Botes have all passed late fitness tests to take their place in the starting XV.
Lambie will replace Louis Ludik, who drops to the bench alongside Alberts and Botes, while there is also a start for Jandre Marais in the second row.
The Cheetahs will hand South Africa Sevens star Johannes Prinsloo his first Super Rugby cap.
Prinsloo replaces the injured Justin Downey at No.8, while Philip Snyman comes in on the wing and Jacques Coetzee starts on the bench.
Sharks: 15 Patrick Lambie, 14 JP Pietersen, 13 Tim Whitehead, 12 Francois Steyn, 11 Lwazi Mvovo, 10 Frederic Michalak, 9 Charl McLeod, 8 Ryan Kankowski, 7 Marcell Coetzee, 6 Keegan Daniel (capt), 5 Anton Bresler, 4 Jandre Marais, 3 Jannie du Plessis, 2 Craig Burden, 1 Tendai Mtawarira.
Replacements: 16 Bismarck du Plessis, 17 Wiehahn Herbst, 18 Pieter-Steph du Toit/Jean Deysel, 19 Willem Alberts, 20 Jacques Botes, 21 Meyer Bosman/Paul Jordaan, 22 Louis Ludik.
Cheetahs: 15 Willie le Roux, 14 Nico Scheepers, 13 Robert Ebersohn, 12 Barry Geel, 11 Philip Snyman, 10 Riaan Smit, 9 Piet van Zyl, 8 Boom Prinsloo, 7 Pieter Labuschagne, 6 Heinrich Brüssow, 5 Izak van der Westhuizen, 4 Andries Ferreira, 3 WP Nel, 2 Adriaan Strauss (captain), 1 Trevor Nyakane.
Replacements: 16 Hercu Liebenberg, 17 Marcel van der Merwe, 18 Waltie Vermeulen, 19 Ashley Johnson, 20 Jacques Coetzee, 21 Sias Ebersohn, 22 Andries Strauss.
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|Friday 14th March|
|06:35||Chiefs vs Stormers|
|08:40||Melbourne Rebels vs Crusaders|
|Saturday 15th March|
|03:35||Hurricanes vs Cheetahs|
|06:35||Highlanders vs Western Force|
|08:40||Brumbies vs Waratahs|
|13:00||Lions vs Blues|
|15:05||Sharks vs Reds|
|Friday 21st March|
|06:35||Highlanders vs Hurricanes|
|08:40||Waratahs vs Melbourne Rebels|
|Saturday 22nd March|
|06:35||Blues vs Cheetahs|
|08:40||Brumbies vs Stormers|
|11:00||Western Force vs Chiefs|
|15:05||Lions vs Reds|
|17:10||Bulls vs Sharks|
|Friday 28th March|
|06:35||Crusaders vs Hurricanes|
|08:40||Melbourne Rebels vs Brumbies|
|Saturday 29th March|
|06:35||Blues vs Highlanders|
|08:40||Reds vs Stormers|
|13:00||Bulls vs Chiefs|
|15:05||Sharks vs Waratahs|
|Friday 4th April|
|07:35||Highlanders vs Melbourne Rebels|
|09:40||Brumbies vs Blues|
|Saturday 5th April|
|07:35||Hurricanes vs Bulls|
|09:40||Reds vs Western Force|
|13:00||Cheetahs vs Chiefs|
|Saturday 8th March|
|Sharks 37 - 23 Lions|
|Bulls 38 - 22 Blues|
|Western Force 32 - 7 Melbourne Rebels|
|Crusaders 14 - 13 Stormers|
|Friday 7th March|
|Reds 43 - 33 Cheetahs|
|Hurricanes 21 - 29 Brumbies|
|Saturday 1st March|
|Bulls 25 - 17 Lions|
|Western Force 14 - 27 Brumbies|
|Waratahs 32 - 5 Reds|
|Chiefs 21 - 19 Highlanders|
|Friday 28th February|
|Stormers 19 - 18 Hurricanes|
|Melbourne Rebels 35 - 14 Cheetahs|
|Blues 35 - 24 Crusaders|
|Sunday 23rd February|
|Waratahs 43 - 21 Western Force|
|Saturday 22nd February|
|Lions 34 - 10 Stormers|
|Sharks 27 - 9 Hurricanes|
|Brumbies 17 - 27 Reds|
|Highlanders 29 - 21 Blues|
|Friday 21st February|
|Cheetahs 15 - 9 Bulls|
|Crusaders 10 - 18 Chiefs|
|Saturday 15th February|
|Sharks 31 - 16 Bulls|
|Cheetahs 20 - 21 Lions|
Read the thoughts and opinions of Stuart Barnes with skysports.com