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London Irish face an uphill task if they are to move away from the Aviva Premiership drop zone against the Leicester Tigers at Madejski Stadium.
Irish are second from bottom in the table with two wins from 12 while the Tigers have won on three of their last four trips to Reading.
Geordan Murphy, Toby Flood, Graham Kitchener and Jordan Crane all return for Leicester.
Club captain Murphy will make his 200th Premiership appearance as he is included in the starting line-up for the first time since the win over Northampton Saints in early November.
He becomes the 19th player to reach that top-flight landmark, with club colleague George Chuter holding the all-time record with 258 appearances.
Fly-half Flood has recovered from a toe injury and makes his first club appearance since the end of October.
Kitchener comes into the second row for Tigers, and Crane takes the number eight shirt with Thomas Waldrom ruled out by a calf injury picked up in last Saturday's Heineken Cup win over Treviso in Italy.
Marland Yarde has recovered from injury and will start for Irish while Ian Humphreys starts at fly half and Jebb Sinclair joins Declan Danaher and Chris Hala'ufia in the back row.
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Sailosi Tagicakibau, 11 Marland Yarde, 10 Ian Humphreys, 9 Darren Allinson, 1 Max Lahiff, 2 David Paice, 3 Halani Aulika, 4 Bryn Evans, 5 Matt Garvey, 6 Declan Danaher (c), 7 Jebb Sinclair, 8 Chris Hala'ufia.
Replacements: 16 Scott Lawson, 17 Jerry Yanuyanutawa, 18 Leo Halavatau, 19 Kieran Low, 20 Jamie Gibson, 21 Guy Armitage, 22 Shane Geraghty, 23 Jack Moates.
Leicester: 15 Geordan Murphy, 14 Niall Morris, 13 Manusamoa Tuilagi, 12 Anthony Allen, 11 Adam Thompstone, 10 Toby Flood, 9 Ben Youngs, 8 Jordan Crane, 7 Julian Salvi, 6 Brett Deacon, 5 Graham Kitchener, 4 Louis Deacon (c), 3 Dan Cole, 2 Tom Youngs, 1 Marcos Ayerza.
Replacements: 16 Rob Hawkins, 17 Logovi'i Mulipola, 18 Fraser Balmain, 19 Ed Slater, 20 Geoff Parling, 21 Sam Harrison, 22 George Ford, 23 Matt Smith.
"It will be great to be playing back at the Madejski in front of our home crow.
"Leicester has been the benchmark team in the Aviva Premiership for a long time now and they'll give us a thorough examination. In saying that we don't fear any team in this league and the boys are itching to play the Tigers."
"We have come out on top of some close games down there in recent years and we have to make sure that doesn't change. They have some good open-field runners and we will have to improve from last week against a team that is better than their position in the table."
Don't miss any live and exclusive rugby union coverage this festive season. Click here to visit Sky Sports' Festive Calendar
|Click here for more betting|
|Friday 2nd May|
|19:45||Bath vs Northampton|
|Saturday 3rd May|
|15:00||Saracens vs Worcester|
|15:00||Wasps vs Newcastle|
|15:00||Gloucester vs London Irish|
|15:15||Sale vs Leicester|
|Sunday 4th May|
|14:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Leicester vs Saracens|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 20th April|
|Newcastle 18 - 23 Saracens|
|Northampton 36 - 21 London Irish|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
Read the thoughts and opinions of Stuart Barnes with skysports.com