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Harlequins have made six changes to the starting line-up from the team which beat Zebre in the Heineken Cup as they face Northampton Saints at Franklin's Gardens.
For Saturday's round 11 clash, amongst the backs will be Tom Williams starting on the right, with Ugo Monye moving to the left wing.
James Johnston and Joe Marler return to start in the front row alongside Joe Gray at hooker. Maurie Fa'asavalu is named in the back-row with Olly Kohn partnering George Robson in the second row.
Among the replacements is Dave Ward, coming in for Rob Buchanan who picked up a knock during the Aviva 'A' League final victory on Monday.
Mark Lambert will also be hoping to make his 100th appearance for the club from the bench this weekend.
Meanwhile, as they prepare to face league leaders Quins, Saints have named just one change, bringing in Courtney Lawes to the second row.
Northampton Saints: 15 Ben Foden, 14 Ken Pisi, 13 George Pisi, 12 Tom May, 11 Jamie Elliott, 10 Stephen Myler, 9 Lee Dickson, 8 Gerrit-Jan van Velze, 7 Phil Dowson, 6 Tom Wood, 5 Courtney Lawes, 4 Samu Manoa, 3 Paul Doran-Jones, 2 Mikey Haywood, 1 Soane Tonga'uiha.
Replacements: 16 Ross McMillan, 17 Alex Waller, 18 Brian Mujati, 19 Mark Sorenson, 20 Calum Clark, 21 Martin Roberts, 22 Ryan Lamb, 23 Luther Burrell.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 Matt Hopper, 12 Tom Casson, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.
Replacements: 16 Dave Ward, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Tom Guest, 21 Karl Dickson, 22 Ben Botica, 23 Sam Smith.
"We enjoyed last Saturday's result, but all the chat in the dressing room was about taking the momentum into tomorrow's game against Harlequins.
"This has been reflected in the attitude in training this week, which has been both intense and positive.
"We all know that Harlequins will pose us plenty of challenges. They are on a good run of form at the moment in all competitions and have shown regularly that they have the temperament and ability to win on the biggest stage.
"But we know we can win the big games, too, and are determined to give our fans something to sing about on Saturday."
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|Click here for more betting|
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale Sharks vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com