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Harlequins will have the services of ace fly-half Nick Evans available to them when they host Exeter in an Aviva Premiership clash on Saturday.
Evans has been sidelined by an ankle injury but returns to action at the expense of Ben Botica who drops to the bench.
Conor O'Shea has made two further changes to the team that beat Sale last weekend. Skipper Nick Easter moves from number eight into the second row in place of Charlie Matthews with Tom Guest taking over at the back of the scrum.
Exeter enter the encounter with the defending champions on a high after thrashing London Welsh 47-16 last time out.
The victory came at a price though, with prop Hoani Tui, lock Dean Mumm and centre Jason Shoemark all ruled out through injury.
The trio are replaced by Alex Brown, Damian Welch and Phil Dollman respectively.
Harlequins: 15 Ollie Lindsay-Hague, 14 Tom Williams, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Nick Evans, 9 Karl Dickson, 8 Tom Guest, 7 Luke Wallace, 6 Maurie Fa'asavalu, 5 George Robson, 4 Nick Easter (C), 3 James Johnston, 2 Joe Gray, 1 Mark Lambert.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Charlie Matthews, 20 Joe Trayfoot, 21 Jordan Burns, 22 Ben Botica, 23 George
Exeter Chiefs: 15 Luke Arscott, 14 Jack Nowell, 13 Sireli Naqelevuki, 12 Phil Dollman, 11 Matt Jess, 10 Gareth Steenson, 9 Haydn Thomas, 8 RichardBaxter, 7 James Scaysbrook, 6 Ben White, 5 Damian Welch, 4 Tom Hayes, 3 Alex Brown, 2 Jack Yeandle, 1 Carl Rimmer.
Replacements: 16 Neil Clark, 17 Ben Moon, 18 Craig Mitchell, 19 James Hanks, 20 Dave Ewers, 21 Will Chudley, 22 Ignacio Mieres, 23 Ian Whitten.
"Last week was a very good performance from us, but now we've got to make sure London Welsh was not a one-off performance and that we show the same enthusiasm and attacking intent for the rest of the season."
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|Friday 20th December|
|19:45||Sale vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:15||Saracens vs Leicester|
|Sunday 22nd December|
|14:00||Gloucester vs Worcester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|Sunday 5th January|
|14:00||Leicester vs Bath|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Exeter vs Northampton|
|15:00||Bath vs Newcastle|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
Read the thoughts and opinions of Stuart Barnes with skysports.com