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Gloucester enter Saturday's clash with London Welsh chasing a top-four spot, while the visitors remain rooted at the foot of the table.
The Exiles enter the clash at Kingsholm bottom of the table after being handed a five-point deduction for fielding an ineligible player earlier in the season.
Recent form for London Welsh has been poor with seven successive defeats in all competitions.
Hosts Gloucester have lost two of their last four Aviva Premiership encounters and will look to get back to winning ways as they seek a play-off spot.
Gloucester coach Nigel Davies makes a number of changes to his side as players return from international duty.
Scotland's Jim Hamilton comes straight back into the side as captain following the Six Nations finale, while Billy Twelvetrees starts after featuring in England's campaign.
In a new look pack, Davies names Huia Edmonds and Shaun Knight in the front row while Andy Hazell and Peter Buxton get the nod on the flanks.
Meanwhile the visitors make five changes ahead of the Kingsholm clash with Seb Jewell, Gonzalo Tiesi, Dan George and Daniel Browne all making the starting XV.
Jewell replaces the injured Tom Arscott at inside centre while Tiesi returns to the number 13 jersey after an injury lay-off.
London Welsh coach Lyn Jones has opted for George in the front row with Greg Bateman demoted to the bench, while Browne starts at number eight against his former club with Alfie To'oala missing out.
Gloucester: 15 Rob Cook, 14 Charlie Sharples, 13 Mike Tindall, 12 Billy Twelvetrees, 11 Jonny May, 10 Freddie Burns, 9 Dan Robson, 8 Sione Kalamafoni, 7 Andy Hazell, 6 Peter Buxton, 5 Will James, 4 Jim Hamilton (capt), 3 Shaun Knight, 2 Huia Edmonds, 1 Nick Wood.
Replacements: 16 Koree Britton, 17 Yann Thomas, 18 Dario Chistolini, 19 Tom Savage, 20 Akapusi Qera, 21 Dave Lewis, 22 Henry Trinder, 23 Martyn Thomas.
London Welsh: 15 Seb Jewell, 14 Phil MacKenzie, 13 Gonzalo Tiesi, 12 Sonny Parker, 11 Seb Stegmann, 10 Gavin Henson, 9 Tyson Keats, 8 Daniel Browne, 7 Michael Hills, 6 Julio Cabello Farias, 5 Kirill Kulemin, 4 Jonathan Mills (capt), 3 James Tideswell, 2 Greg Dan George, 1 Tom Bristow.
Replacements: 16 Greg Bateman, 17 Billy Moss, 18 Arthur Joly, 19 Matt Corker, 20 Adam Balding, 21 Alex Davies, 22 Gordon Ross, 23 Nick Scott.
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|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com