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Harlequins have named four changes to their side ahead of Saturday's Aviva Premiership clash against Northampton Saints at the Twickenham Stoop.
Tom Casson comes into the side at centre to partner George Lowe having missed out on the win against Worcester Warriors two weeks ago.
In the forward line Rob Buchanan starts at hooker while Tom Guest comes in to replace Maurie Fa'asavalu in the back row.
England captain Chris Robshaw is unavailable having picked up a knock against Worcester but Harlequins coach Conor O'Shea expects the forward to be fit to feature in next week's Premiership semi-final.
The visiting Northampton Saints have also made four changes to their squad which beat Sale time out to secure a play-off position.
George Pisi returns to the starting XV at outside centre in place of Tom May as the Saints look to leapfrog Harlequins in the Premiership standings.
In the pack Samu Manoa takes the number eight jersey ahead of GJ van Velze who is demoted to the bench while Calum Clark returns in the flanks to partner Tom Wood.
Both sides head into the clash with back-to-back wins and just one point between them meaning the victor will take third place in the Premiership table.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 George Lowe, 12 Tom Casson, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Luke Wallace, 6 Tom Guest, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Rob Buchanan, 1 Joe Marler.
Replacements: 16 Joe Gray, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Maurie Fa'asavalu, 21 Karl Dickson, 22 Ben Botica, 23 Ross Chisholm.
Northampton: 15 Ben Foden, 14 Ken Pisi, 13 George Pisi, 12 Luther Burrell, 11 Jamie Elliott, 10 Stephen Myler, 9 Lee Dickson, 8 Samu Manoa, 7 Tom Wood, 6 Calum Clark, 5 Christian Day, 4 Courtney Lawes, 3 Brian Mujati, 2 Dylan Hartley (capt), 1 Soane Tonga'uiha.
Replacements: 16 Mike Haywood, 17 Alex Waller, 18 Tom Mercey, 19 Phil Dowson, 20 GJ van Velze, 21 Martin Roberts, 22 Ryan Lamb, 23 James Wilson.
"At this stage of the season it is all about trying to build some momentum and get into a the habit of winning.
"We have had a great season, we had a little blip after Christmas during the Six Nations when we lost our top of the table spot but if you look back at the results our percentage of wins is really high."
"It's a chance to play against a top side, to test ourselves as best as we can and see where we stand at the end of the game.
"We're going to be coming up against another good team in the semi-final and potentially another one in the final."
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|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com