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Harlequins will field the same side that won last year's Premiership final as they look to book their return to the play-offs with a win over Worcester at Sixways.
Quins boss Conor O'Shea names his title-winning XV for the first time this season, knowing that a win will book their play-off place after they ended a run of three successive defeats last week by beating Bath.
James Johnston will make his 100th appearance for the club and is named in the front-row with Joe Gray and Joe Marler, while George Robson has recovered from a knock he picked up last week and starts in the second-row, while Nick Easter, who starts at number eight, will make his 200th appearance for the club.
There are two changes in the backline from the side that defeated Bath last weekend as Jordan Turner-Hall is named at inside centre, while Ugo Monye starts on the left wing.
Matt Hopper had surgery on a finger injury on Monday and will be out for 14 weeks, while Tom Casson is still struggling with a knee injury sustained against Munster.
Worcester have lost eight out of their last nine games and have been beaten by Harlequins in each of their last 11 meetings, but will hope to end that streak in what will be Andy Goode's last appearance at Sixways before he joins Wasps.
Worcester wing Ben Howard will make his first Premiership start and Jon Clarke is named at inside centre in place of the suspended Josh Matavesi.
Matt Mullan and Matt Kvesic will also be making their final Sixways appearances for the Warriors before moving to Gloucester and London Wasps respectively.
Craig Gillies and Shaun Perry are recalled to the bench as Warriors search for their sixth Premiership win of the season.
Worcester: 15 Chris Pennell, 14 Josh Drauniniu, 13 Alex Grove, 12 Jon Clarke, 11 Ben Howard, 10 Andy Goode, 9 Jonny Arr, 8 Semisi Taulava, 7 Matt Kvesic, 6 Neil Best, 5 Chris Jones, 4 James Percival (c), 3 Euan Murray, 2 Ed Shervington, 1 Matt Mullan.
Replacements: 16 Aleki Lutui, 17 Rob O'Donnell, 18 John Andress, 19 Craig Gillies, 20 Jake Abbott, 21 Shaun Perry, 22 Danny Gray, 23 Joe Carlisle.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 George Lowe, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw, 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Tom Guest,, 21 Karl Dickson, 22 Ben Botica, 23 Ross Chisholm.
Worcester coach Nigel Redman
"We have picked a team with a lot of Worcester influence and we want the players to give that extra bit. If they all do that, it will be enough.
"It's important for everyone concerned that we play with intent. Every game is a fresh occasion and a new opportunity and we will play with a positive mindset and aim to win the game.
"We have been competitive in most matches this season. Sometimes we have come up short and we are all responsible for that. When you look at our performances in some of our matches, we have looked like a very good team.
"We expect Harlequins to arrive at Sixways and play like champions. They won the Aviva Premiership title last season and will come here looking to secure a top four place."
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|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com