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Off-season signings James Downey and Casey Laulala will start in the Munster midfield for Saturday PRO12 opener against Edinburgh.
The duo are joined in the starting line-up by fellow newcomer Sean Dougall plus international Donncha O'Callaghan for the clash at Murrayfield.
The only uncapped player in the squad, led for the first time competitively by Doug Howlett in his new role as captain, is forward Barry O'Mahony.
Downey and Laulala form the midfield pairing and after an impressive debut season in which he scored four tries, while Luke O'Dea is named on the left.
In the front row Damien Varley is propped by the South African pair Wian du Preez and BJ Botha.
O'Callaghan is partnered by the hard working Billy Holland and Dougall is joined in the back-row by youth and experience in the shape of Paddy Butler while the dependable James Coughlan starts at number eight.
But new coach Rob Penney knows there will be no easy start to the season for his side against Michael Bradley's men in the Scottish capital.
Bradley will not name his side until Friday but can welcome back a number of his internationals who were involved in the triumphant three Test Australasia tour.
Skipper Greig Laidlaw, Tim Visser, Nick De Luca, Ross Ford and Ross Rennie are all available for selection, while David Denton has returned to full training after the ankle injury that ruled him out of the summer tour.
Edinburgh: 15 Greig Tonks, 14 Lee Jones, 13 Nick De Luca, 12 Ben Atiga, 11 Tim Visser, 10 Greig Laidlaw (capt), 9 Richie Rees, 8 Stuart McInally, 7 Ross Rennie, 6 David Denton, 5 Sean Cox, 4 Grant Gilchrist, 3 Willem Nel, 2 Ross Ford, 1 John Yapp
Replacements: 16 Andy Titterrell, 17 Allan Jacobsen, 18 Geoff Cross, 19 Perry Parker, 20 Dimitri Basilaia, 21 Chris Leck, 22 Gregor Hunter, 23 John Houston
Munster: 15 Denis Hurley, 14 Doug Howlett (capt), 13 Casey Laulala, 12 James Downey, 11 Luke O'Dea, 10 Ian Keatley, 9 Duncan Williams, 8 James Coughlan, 7 Sean Dougall, 6 Peter Butler, 5 Billy Holland, 4 Donncha O'Callaghan, 3 BJ Botha, 2 Damien Varley, 1 Wian du Preez
Replacements: 16 Mike Sherry, 17 Marcus Horan, 18 Stephen Archer, 19 Dave Foley, 20 Barry O'Mahony, 21 Peter Stringer, 22 Scott Deasy, 23 Ivan Dineen
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|Friday 18th April|
|17:00||Leinster vs Benetton Treviso|
|19:35||Glasgow vs Ulster|
|Saturday 19th April|
|14:30||Zebre vs Edinburgh|
|18:15||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Glasgow vs Zebre|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
|Ospreys 34 - 9 Cardiff Blues|
|Friday 14th March|
|Ulster 26 - 13 Scarlets|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
Read the thoughts and opinions of Stuart Barnes with skysports.com