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Former Western Province lock Quinn Roux will make his home debut for Leinster in Saturday's PRO12 clash with the Dragons in Dublin.
Roux partners skipper Leo Cullen in the second row while another home debut is handed to Leinster Academy flanker Ben Marshall.
Marshall, who made his first appearance for the province away to Ulster in December 2010, comes into the back-row alongside Shane Jennings and number eight Leo Auva'a.
Ireland hooker Sean Cronin is included in the front row alongside Jamie Hagan and Jack McGrath, while John Cooney will link up with Ian Madigan at half-back in the absence of the injured Isaac Boss.
The rest of Leinster's largely fledgling back-line that started last weekend's game in Llanelli remains the same, aside from the experienced Isa Nacewa who will make his 104th appearance.
Devin Toner is named on the replacements bench alongside prop Heinke van der Merwe.
Meanwhile, Dragons back row Jevon Groves will lead the men of Gwent for the first time after being named as skipper.
Although this is his first outing as Dragons captain, he is no stranger to the position, having captained the Wales Sevens team to the plate semi-finals during the 2010 Commonwealth Games.
Fellow back-row and regional captain Lewis Evans makes his return from injury from the bench whilst prop Tim Ryan starts his competitive career at the Dragons as a replacement.
With an unchanged back-line from the 37-6 victory over the Zebre last week, head coach Darren Edwards has rung the changes in the forwards with Groves, Ian Nimmo and Toby Faletau the only survivors from last weekend's starting line-up.
Leinster: 15 Isa Nacewa, 14 Andrew Conway, 13 Brendan Macken, 12 Noel Reid, 11 Fionn Carr, 10 Ian Madigan, 9 John Cooney, 8 Leo Auva'a, 7 Shane Jennings, 6 Ben Marshall, 5 Quinn Roux, 4 Leo Cullen (c), 3 Jamie Hagan, 2 Sean Cronin, 1 Jack McGrath.
Replacements: 16 Tom Sexton 17 Heinke van der Merwe 18 Martin Moore 19 Devin Toner 20 Jordi Murphy 21 Luke McGrath 22 Colm O'Shea 23 Darren Hudson.
Newport Gwent Dragons: 15 Dan Evans, 14 Will Harries, 13 Pat Leach, 12 Andy Tuilagi, 11 Tom Prydie, 10 Steffan Jones, 9 Jonathan Evans, 8 Toby Faletau, 7 Jevon Groves (c), 6 Hywel Stoddart, 5 Adam Jones, 4 Ian Nimmo, 3 Nathan Buck, 2 Sam Parry, 1 Nathan Williams.
Replacements: 16 Hugh Gustafson, 17 Aaron Coundley, 18 Tim Ryan, 19 Lewis Evans, 20 Tom Brown, 21 Liam Davies (Bedwas), 22 Ashley Smith, 23 Hallam Amos.
Date: Saturday, September 8
Venue: RDS, Dublin
Kick-off: 18.15 BST (17.15 GMT)
Referee: Marius Mitrea
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|Friday 18th April|
|17:00||Leinster vs Benetton Treviso|
|19:35||Glasgow vs Ulster|
|Saturday 19th April|
|14:30||Zebre vs Edinburgh|
|18:15||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Glasgow vs Zebre|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
|Ospreys 34 - 9 Cardiff Blues|
|Friday 14th March|
|Ulster 26 - 13 Scarlets|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
Read the thoughts and opinions of Stuart Barnes with skysports.com