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Defending RaboDirect PRO12 champions Ospreys go in search of their fourth successive victory when they tackle Connacht at the Liberty Stadium on Saturday.
The home side have made two changes to their starting side as blindside flanker Joe Bearman and tighthead prop Aaron Jarvis come in for Ryan Jones and Adam Jones.
The backline remains unchanged as the Welsh region look to bounce back from their disappointing Heineken Cup finish against Leicester at Welford Road last weekend.
Connacht coach Eric Elwood has made seven changes. Two of those changes are positional with George Naoupu moving from his regular number eight position to lock in place of an injured Mike McCarthy while Robbie Henshaw replaces Eoin Griffin.
Mata Fifita replaces Dave McSharry and joins Henshaw in the new centre partnership. Darragh Leader, 19, earns his first competitive start for the province at full-back.
On the bench, former Stormers player Danie Poolman is set to make his first appearance for the province. Rodney Ah You and Dave Gannon also return to the bench as forwards.
Ospreys: 15 Richard Fussell, 14 Hanno Dirksen, 13 Andrew Bishop, 12 Ashley Beck, 11 Eli Walker, 10 Dan Biggar, 9 Kahn Fotuali'i, 8 Jonathan Thomas, 7 Justin Tipuric, 6 Joe Bearman, 5 Ian Evans, 4 Alun Wyn Jones (cpt), 3 Aaron Jarvis, 2 Richard Hibbard, 1 Ryan Bevington.
Replacements: 16 Matthew Dwyer, 17 Duncan Jones, 18 Joe Rees, 19 James King, 20 George Stowers, 21 Rhys Webb, 22 Matthew Morgan, 23 Tom Isaacs.
Connacht: 15 Darragh Leader, 14 Tiernan O'Halloran, 13 Robbie Henshaw, 12 Mata Fifita, 11 Fetu'u Vainikolo, 10 Dan Parks, 9 Kieran Marmion, 8 Eoin McKeon, 7 Willie Faloon, 6 John Muldoon, 5 George Naoupu, 4 Michael Swift, 3 Nathan White (cpt), 2 Jason Harris-Wright, 1 Brett Wilkinson.
Replacements: 16 Adrian Flavin, 17 Ronan Loughney, 18 Rodney Ah You, 19 Dave Gannon, 20 Johnny O'Connor, 21 Dave Moore, 22 Miah Nikora, 23 Danie Poolman.
"Connacht are a very dangerous team, Eric Elwood has taken what was already a tough, physical group and looked to expand their game," said Humphreys.
"We know that we are going to have be well prepared, diligent and focused if we are going to get what we want out of this fixture, and it'll need to be a real team effort on and off the field."
"Over the years, we've had huge physical encounters with the Welsh side and we'll be expecting the same this weekend. It's another big challenge but we take great encouragement from our performances of the last few weeks," he Elwood.
"Last Saturday, we went toe-to-toe with the English champions and competed with them for the 80 minutes. We played some great rugby and we'll be looking to do the same this weekend against the Ospreys.
"We know it's going to be a hugely physical battle but we're very much looking forward to the test. The goal for us is to keep improving and continue on our upward curve."
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|Saturday 25th May|
|16:45||Ulster vs Leinster|
|Saturday 11th May|
|Leinster 17 - 15 Glasgow|
|Friday 10th May|
|Ulster 28 - 17 Scarlets|
|Friday 3rd May|
|Edinburgh 31 - 24 Newport Gwent D'gons|
|Connacht 3 - 20 Glasgow|
|Zebre 25 - 27 Munster|
|Scarlets 17 - 41 Benetton Treviso|
|Leinster 37 - 19 Ospreys|
|Ulster 37 - 13 Cardiff Blues|
|Friday 26th April|
|Benetton Treviso 23 - 23 Connacht|
|Sunday 21st April|
|Zebre 22 - 41 Leinster|
|Saturday 20th April|
|Scarlets 24 - 6 Cardiff Blues|
|Friday 19th April|
|Connacht 18 - 34 Ulster|
|Glasgow 35 - 17 Ospreys|
|Benetton Treviso 30 - 10 Edinburgh|
|Newport Gwent D'gons 30 - 24 Munster|
|Saturday 13th April|
|Ospreys 28 - 3 Benetton Treviso|
|Munster 16 - 22 Leinster|
|Cardiff Blues 28 - 13 Zebre|
|Friday 12th April|
|Edinburgh 24 - 32 Connacht|
|Ulster 31 - 5 Newport Gwent D'gons|
|Scarlets 29 - 6 Glasgow|
Read the thoughts and opinions of Stuart Barnes with skysports.com