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Munster have named only three players who featured in their last RaboDirect PRO12 game in their starting line-up for Saturday's clash with Edinburgh at Musgrave Park.
Nine who started in the defeat to Cardiff Blues in January are either injured or involved with Ireland, while three more - Mike Sherry, Dave Foley and Tommy O'Donnell - are named on the bench.
There's a first start of the season for Danny Barnes and Ivan Dineen, while JJ Hanrahan, Johne Murphy and Ian Nagle all get their second start of the year.
CJ Stander returns to the side after breaking a bone in his hand in the game against Glasgow back at the start of December, though he has featured in recent British & Irish Cup games, and did come on as a replacement here in January against the Blues.
Edinburgh will be looking to snap a poor run of results which has seen them lose their last seven matches in all competitions.
Head coach Michael Bradley has been able to call on the services of Wales international prop John Yapp, South African lock Izak van der Westhuizen and Scotland wing Tom Brown, the latter returning after two months out with injury.
Also available again are Ben Cairns (centre), Dougie Fife (wing), full-back Greig Tonks and (back-row) Stuart McInally, who will make his 50th appearance for the club.
Munster: 15 Denis Hurley, 14 Johne Murphy, 13 Ivan Dineen, 12 JJ Hanrahan, 11 Danny Barnes, 10 Ian Keatley, 9 Duncan Williams, 8 James Coughlan (capt), 7 Sean Dougall, 6 CJ Stander, 5 Billy Holland, 4 Ian Nagle, 3 BJ Botha, 2 Damien Varley, 1 Marcus Horan
Replacements: 16 Mike Sherry, 17 Wian du Preez, 18 J Ryan, 19 Dave Foley, 20 Tommy O'Donnell, 21 Paddy Butler, C Sheridan, Scott Deasy
Edinburgh: 15 Greig Tonks, 14 Dougie Fife, 13 Ben Cairns, 12 Ben Atiga, 11 Tom Brown, 10 Piers Francis, 9 Richie Rees; 1 John Yapp, 2 Andy Titterrell, 3 Willem Nel, 4 Perry Parker, 5 Izak van der Westhuizen, 6 Sean Cox (capt), 7 Stuart McInally, 8 Netani Talei
Replacements: 16 Steven Lawrie, 17 Allan Jacobsen, 18 Alex Allan, 19 Grant Gilchrist, 20 Hamish Watson, 21 Chris Leck, 22 Gregor Hunter, 23 Lee Jones
|Click here for more betting|
|Saturday 25th May|
|Ulster 18 - 24 Leinster|
|Saturday 11th May|
|Leinster 17 - 15 Glasgow|
|Friday 10th May|
|Ulster 28 - 17 Scarlets|
|Friday 3rd May|
|Edinburgh 31 - 24 Newport Gwent D'gons|
|Connacht 3 - 20 Glasgow|
|Zebre 25 - 27 Munster|
|Ulster 37 - 13 Cardiff Blues|
|Leinster 37 - 19 Ospreys|
|Scarlets 17 - 41 Benetton Treviso|
Read the thoughts and opinions of Stuart Barnes with skysports.com