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Newport Gwent Dragons have made wholesale changes to their side ahead of Saturday's encounter with Scarlets at the Millennium Stadium.
Welsh team officials have championed this weekend's RaboDirect PRO12 fixtures with two derbies on offer.
First up the Dragons take on Scarlets, before Cardiff Blues face the Ospreys in a double-header at the national stadium.
Wales internationals Toby Faletau and Dan Lydiate are named in the Dragons back row alongside Nic Cudd who retains his place at openside flanker.
But they are without loosehead prop Phil Price, who will undergo knee surgery next week, although Aaron Coundley, Hugh Gustafson and Dan Way all return to the front row.
Following a successful Six Nations campaign with Wales Andrew Coombs leads the Dragons out as they make their first appearance at the national stadium.
Meanwhile, the Scarlets welcome their Wales international contingent back to the starting line-up as coach Simon Easterby seeks a third successive victory.
Centres Jonathan Davies and Scott Williams return to the side with Gareth Maule dropping to the bench and Adam Warren left out of the squad.
On the wings George North and Liam Williams get the nod leaving Andy Fenby out of side while Matthew Rees starts at hooker.
Dragons: 15 Tom Prydie, 14 Will Harries, 13 Pat Leach, 12 Jack Dixon, 11 Ross Wardle, 10 Dan Evans, 9 Jonathan Evans, 8 Toby Faletau 7 Nic Cudd, 6 Dan Lydiate, 5 Rob Sidoli, 4 Andrew Coombs (capt), 3 Dan Way, 2 Hugh Gustafson, 1 Aaron Coundley. Replacements: 16 Sam Parry, 17 Owen Evans, 18 Nathan Buck, 19 Jevon Groves, 20 Ieuan Jones, 21 Wayne Evans, 22 Steffan Jones, 23 Adam Hughes.
Scarlets: 15 Gareth Owen, 14 George North, 13 Jonathan Davies, 12 Scott Williams, 11 Liam Williams, 10 Owen Williams, 9 Aled Davies, 8 Rob McCusker (capt), 7 Johnathan Edwards, 6 Aaron Shingler, 5 Johan Synman, 4 George Earle, 3 Samson Lee, 2 Matthew Rees, 1 Phil John.
Replacements: 16 Ken Owens, 17 Rhodri Jones, 18 Deacon Manu, 19 Sione Timani, 20 Josh Turnbull, 21 Rhodri Williams, 22 Aled Thomas, 23 Gareth Maule.
"The boys have prepared well - it's been an intense training week at Parc y Scarlets with plenty of competition to get into the starting XV which has really added an edge," he told the club's official website.
"The Millennium Stadium is a special place for both the players and the fans and it's a great concept to have these two derby matches here on the same day the atmosphere will be amazing," he told the club's official website.
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|Friday 14th March|
|19:05||Ulster vs Scarlets|
|Friday 21st March|
|19:05||Ospreys vs Cardiff Blues|
|19:15||Leinster vs Zebre|
|19:45||Edinburgh vs Ulster|
|Saturday 22nd March|
|15:00||Glasgow vs Scarlets|
|19:15||Munster vs Benetton Treviso|
|Sunday 23rd March|
|15:05||Newport Gwent D'gons vs Connacht|
|Saturday 29th March|
|15:00||Zebre vs Newport Gwent D'gons|
|18:00||Benetton Treviso vs Edinburgh|
|18:30||Cardiff Blues vs Ulster|
|19:00||Leinster vs Munster|
|Sunday 30th March|
|14:05||Scarlets vs Connacht|
|Thursday 3rd April|
|18:30||Newport Gwent D'gons vs Edinburgh|
|Friday 11th April|
|19:05||Ulster vs Connacht|
|19:05||Ospreys vs Leinster|
|19:45||Edinburgh vs Cardiff Blues|
|Saturday 12th April|
|18:00||Benetton Treviso vs Newport Gwent D'gons|
|18:30||Munster vs Glasgow|
|18:30||Scarlets vs Zebre|
|Saturday 19th April|
|15:00||Zebre vs Edinburgh|
|15:00||Glasgow vs Ulster|
|15:00||Leinster vs Benetton Treviso|
|15:00||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
|Friday 28th February|
|Edinburgh 31 - 25 Ospreys|
|Ulster 38 - 8 Newport Gwent D'gons|
|Sunday 23rd February|
|Zebre 19 - 27 Connacht|
|Ospreys 11 - 25 Munster|
|Newport Gwent D'gons 24 - 23 Glasgow|
|Benetton Treviso 12 - 14 Ulster|
|Saturday 22nd February|
|Scarlets 25 - 21 Edinburgh|
|Thursday 20th February|
|Cardiff Blues 22 - 34 Leinster|
|Sunday 16th February|
|Ospreys 75 - 7 Benetton Treviso|
|Saturday 15th February|
|Munster 36 - 8 Zebre|
|Cardiff Blues 20 - 27 Glasgow|
|Connacht 11 - 7 Edinburgh|
|Friday 14th February|
|Leinster 31 - 19 Newport Gwent D'gons|
|Sunday 9th February|
|Zebre 8 - 31 Leinster|
|Glasgow 8 - 6 Connacht|
|Saturday 8th February|
|Munster 54 - 13 Cardiff Blues|
|Benetton Treviso 33 - 41 Scarlets|
|Friday 7th February|
|Ulster 10 - 7 Ospreys|
Read the thoughts and opinions of Stuart Barnes with skysports.com