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Fit-again Stephen Ferris will return to Ulster's starting XV for Friday's RaboDirect PRO12 home clash with Edinburgh.
Ferris will take his place at blindside flanker with Mike McComish and Roger Wilson completing the back row.
Coach Mark Anscombe has made numerous other changes to his line-up with Nigel Brady (captain), Callum Black and John Afoa featuring in a new-look front row, while development prop Ricky Lutton will make his senior debut if he makes it on from the bench.
Another youngster, Ricky Andrew, will make his first start for the club after being selected at full-back, but the experienced half-back pairing of Paul Marshall and Ruan Pienaar remains in place from last week's thumping win over the Dragons.
With Greig Laidlaw unavailable, Edinburgh will be led by lock forward Sean Cox at Ravenhill on Friday.
The versatile Cox starts at blindside in a new-look back-row with Roddy Grant and McInally and Robert McAlpine is given the nod to replace him in the second row.
Scotland Test hopefuls Grant Gilchrist, Stuart McInally and Lee Jones all return to the starting line-up, while prop Allan Jacobsen continues his recovery from a hamstring injury by earning a place on the bench.
John Houston returns to the centres to partner James King, who starts his first match of the season, while fly-half Gregor Hunter replaces the injured Harry Leonard at ten.
Ulster: 15 Ricky Andrew, 14 Chris Cochrane, 13 Jared Payne, 12 Paddy Wallace, 11 Craig Gilroy, 10 Ruan Pienaar, 9 Paul Marshall, 8 Roger Wilson, 7 Mike McComish, 6 Stephen Ferris, 5 Neil McComb, 4 Lewis Stevenson, 3 John Afoa, 2 Nigel Brady (capt), 1 Callum Black.
Replacements: 16 Niall Annett, 17 Ricky Lutton, 18 Adam Macklin, 19 Robbie Diack, 20 Nick Williams, 21 Niall O'Connor, 22 Stuart Olding, 23 Peter Nelson
Edinburgh: 15 Greig Tonks, 14 Lee Jones, 13 John Houston, 12 James King, 11 Tom Brown, 10 Gregor Hunter, 9 Chris Leck, 8 Stuart McInally, 7 Roddy Grant, 6 Sean Cox (capt), 5 Robert McAlpine, 4 Grant Gilchrist, 3 Willem Nel, 2 Andy Titterrell, 1 John Yapp.
Replacements: 16 Alun Walker, 17 Allan Jacobsen, 18 Lewis Niven, 19 Izak van der Westhuizen, 20 Hamish Watson, 21 Richie Rees, 22 Dougie Fife, 23 Sep Visser
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|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Glasgow vs Zebre|
|Sunday 20th April|
|Newport Gwent D'gons 10 - 20 Ospreys|
|Cardiff Blues 17 - 13 Scarlets|
|Saturday 19th April|
|Connacht 23 - 32 Munster|
|Zebre 26 - 13 Edinburgh|
|Friday 18th April|
|Glasgow 27 - 9 Ulster|
|Leinster 62 - 7 Benetton Treviso|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
Read the thoughts and opinions of Stuart Barnes with skysports.com