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Edinburgh have made six changes to their line-up for Friday's RaboDirect PRO12 clash with defending champions Ospreys.
Crucially the Murrayfield-based side will welcome back British and Irish Lions hooker Ross Ford to their line-up.
Izak van der Westhuizen and Perry Parker also come into the pack, while Sep Visser, Dougie Fife and Richie Rees added to the back division.
Head coach Michael Bradley, though, is without a number of players with Geoff Cross, Nick De Luca, David Denton, Grant Gilchrist, Greig Laidlaw, Matt Scott, Tim Visser all on international duty.
Andrew Bishop will set a new appearance record for the Ospreys when he lines up in the centres.
Bishop, whose debut came against the Borders in 2005, will be making his 181st appearance for the region, moving ahead of Paul James at the top of the list.
At the other end of the spectrum, Owen Williams makes his RaboDirect PRO12 debut - with Nicky Thomas set for his first domestic appearance if he comes off the bench.
Edinburgh: 15 Greig Tonks, 14 Sep Visser, 13 Dougie Fife, 12 James King, 11 Tom Brown, 10 Gregor Hunter, 9 Richie Rees, 1 John Yapp, 2 Ross Ford, 3 Willem Nel, 4 Perry Parker, 5 Izak van der Westhuizen, 6 Sean Cox (capt), 7 Roddy Grant, 8 Stuart McInally.
Replacements: 16 Alun Walker, 17 Allan Jacobsen, 18 Lewis Niven, 19 Robert McAlpine, 20 Hamish Watson, 21 Chris Leck, 22 John Houston, 23 Mike Penn
Ospreys: 15 Richard Fussell, 14 Tom Isaacs, 13 Andrew Bishop, 12 Jonathan Spratt, 11 Eli Walker, 10 Matthew Morgan, 9 Rhys Webb, 1 Ryan Bevington, 2 Scott Baldwin, 3 Owen Williams, 4 Lloyd Peers, 5 James King, 6 George Stowers, 7 Sam Lewis, 8 Joe Bearman (capt).
Replacements: 16 Duncan Jones, 17 Matthew Dwyer, 18 Nicky Thomas, 19 Ian Gough, 20 Morgan Allen, 21 Tom Habberfield, 22 Matthew Morgan, 23 Ross Jones
"We return for the first match in the 'second phase' of the season and look to get moving against a formidable opponent in the shape of the PRO12 champions.
"They come here full of confidence having won five on the bounce in the league and will be keen to maintain their run and underline their championship credentials.
"Both matches last season were close affairs; at Liberty Stadium they cleared their lines and ran the full length to score in the last minute and here, at Murrayfield, they edged us by a single point, thanks to the converted try-of-the-season from [Hanno] Dirksen."
"This is the first of two big PRO12 games over the next couple of weeks that will really test us. Edinburgh away and then Cardiff Blues home are always tough games, and there's no doubt that we are going to have to show plenty of spirit, commitment and desire on and off the pitch if we are going to get what we want from these matches.
"There's a lot of responsibility on some young shoulders during international periods and it's been pleasing to see players stepping up to the mark and really taking their chances.
"What equally important to us is the input of senior guys like Duncan, Bearman, Gough and Fussell. We've kept hold of a group of experienced players who have the right attitude, knowing that we can mould younger players around them."
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|Friday 20th December|
|19:05||Cardiff Blues vs Ospreys|
|19:05||Ulster vs Zebre|
|19:35||Glasgow vs Benetton Treviso|
|19:35||Edinburgh vs Leinster|
|Saturday 21st December|
|17:00||Connacht vs Newport Gwent D'gons|
|19:15||Munster vs Scarlets|
|Thursday 26th December|
|14:00||Scarlets vs Ospreys|
|15:05||Edinburgh vs Glasgow|
|17:00||Newport Gwent D'gons vs Cardiff Blues|
|Friday 27th December|
|19:15||Munster vs Connacht|
|Saturday 28th December|
|15:00||Benetton Treviso vs Zebre|
|18:45||Leinster vs Ulster|
|Wednesday 1st January|
|14:05||Cardiff Blues vs Newport Gwent D'gons|
|18:05||Glasgow vs Edinburgh|
|Friday 3rd January|
|19:05||Ulster vs Munster|
|Saturday 4th January|
|15:00||Zebre vs Benetton Treviso|
|15:00||Connacht vs Leinster|
|15:00||Ospreys vs Scarlets|
|Saturday 8th February|
|15:00||Benetton Treviso vs Scarlets|
|15:00||Newport Gwent D'gons vs Edinburgh|
|15:00||Glasgow vs Connacht|
|15:00||Zebre vs Leinster|
|15:00||Ulster vs Ospreys|
|15:00||Munster vs Cardiff Blues|
|Saturday 15th February|
|15:00||Connacht vs Edinburgh|
|Saturday 30th November|
|Leinster 36 - 19 Scarlets|
|Benetton Treviso 26 - 26 Cardiff Blues|
|Zebre 11 - 19 Ulster|
|Friday 29th November|
|Edinburgh 43 - 10 Connacht|
|Newport Gwent D'gons 14 - 18 Munster|
|Ospreys 16 - 28 Glasgow|
|Sunday 24th November|
|Benetton Treviso 20 - 21 Leinster|
|Saturday 23rd November|
|Cardiff Blues 10 - 31 Munster|
|Connacht 21 - 24 Scarlets|
|Ospreys 30 - 20 Zebre|
|Friday 22nd November|
|Glasgow 8 - 23 Newport Gwent D'gons|
|Ulster 41 - 17 Edinburgh|
|Saturday 2nd November|
|Munster 12 - 6 Ospreys|
|Scarlets 17 - 9 Ulster|
|Connacht 12 - 19 Glasgow|
|Cardiff Blues 17 - 13 Benetton Treviso|
|Friday 1st November|
|Edinburgh 25 - 23 Zebre|
|Newport Gwent D'gons 19 - 23 Leinster|
|Saturday 26th October|
|Leinster 16 - 13 Connacht|
|Friday 25th October|
|Edinburgh 20 - 13 Benetton Treviso|
|Glasgow 6 - 13 Munster|
|Ulster 39 - 21 Cardiff Blues|
|Ospreys 40 - 17 Newport Gwent D'gons|
|Zebre 16 - 16 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com