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Northampton show two changes from the side that defeated Worcester five days ago for the Aviva Premiership clash with Wasps on Friday.
Centre Dom Waldouck replaces George Pisi alongside Luther Burrell in midfield and England flanker Tom Wood features at openside instead of Phil Dowson, who is on bench duty.
Saints are one of only two unbeaten teams in the Aviva Premiership but their director of rugby Jim Mallinder expects a tough test from Wasps.
"They have been very competitive in every game and shown their willingness to play as a team for the full 80 minutes. They soundly beat London Irish two weeks ago and put over 40 points past Harlequins in Round 1 as well," he said.
Prop Tim Payne will make his 250th appearance for Wasps as the Londoners look to bounce back from last weekend's defeat at Gloucester.
Winger James Bailey makes a first-team debut, replacing Tom Varndell, while there are also starts for fly-half Nicky Robinson, flanker Joe Launchbury and No 8 Billy Vunipola.
Stephen Jones has not recovered from stomach illness and his place on the bench has been taken by Lee Thomas.
Northampton: Wilson, K Pisi, Waldouck, Burrell, Artemyev, Myler, Dickson; Tonga'uiha, Hartley (capt), Doran Jones, Manoa, Day, Lawes, Wood, Oakley. Replacements: Haywood, Mujati, Waller, Sorenson, Dowson, Roberts, Lamb, May.
Wasps: T Bell, Wade, Masi, C Bell, Bailey, Robinson, Simpson; Payne, Lindsay, Taufalo, Palmer, Wentzel (capt), Launchbury, Haskell, Vunipola. Replacements: Rhys Thomas, McIntyre, Staibano, Sam Jones, Cannon, Davies, Lee Thomas, Daly.
|Click here for more betting|
|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com