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Sale Sharks have drafted Cameron Shepherd into their starting line-up as they look to secure their first Aviva Premiership win of the season at the eighth time of asking.
The Australia international will make his first start for the Sharks since his summer arrival from Super Rugby outfit Western Force, which followed the collapse of a proposed move to Northampton.
Shepherd's inclusion on the left wing sees Mark Cueto switch to the right, with Tom Brady dropping to the bench.
The only other change from the side beaten at Worcester last time out sees Richie Gray come into the second row for Kearnan Myall.
For London Irish, Marland Yarde has recovered from injury and returns to the Exiles' starting XV on the left wing.
As a result, Sailosi Tagicakibau moves into the centres in place of the absent Jonathan Joseph, while Darren Allinson starts his first match of the season at scrum-half and will form a half-back partnership with Ian Humphreys.
Elsewhere, Scott Lawson starts at hooker and George Skivington is named as a replacement after recovering from injury.
Sale Sharks: 15 Nick Macleod, 14 Mark Cueto, 13 Johnny Leota, 12 Sam Tuitupou, 11 Cameron Shepherd, 10 Danny Cipriani, 9 Cillian Willis, 8 Andy Powell 7 David Seymour (capt ), 6 Richie Vernon, 5 Fraser McKenzie, 4 Richie Gray, 3 Tony Buckley, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Joe Ward, 17 Eifion Lewis-Roberts, 18 Vadim Cobilas, 19 Kearnan Myall, 20 Mark Easter, 21 Dwayne Peel, 22 Rob Miller, 23 Tom Brady
London Irish: 15 Anthony Watson, 14 Topsy Ojo, 13 Guy Armitage, 12 Sailosi Tagicakibau, 11 Marland Yarde, 10 Ian Humphreys, 9 Darren Allinson, 8 Chris Hala'ufia 7 Jamie Gibson, 6 Declan Danaher (Captain), 5 Matt Garvey, 4 Bryn Evans, 3 Halani Aulika, 2 Scott Lawson, 1 Max Lahiff.
Replacements: 16 Brian Blaney, 17 Cai Griffiths, 18 Leo Halavatau, 19 George Skivington, 20 Ofisa Treviranus, 21 Steven Shingler, 22 Shane Geraghty, 23 Jack Moates
"Friday evening will be a big test of how far we have come this season. We played some great rugby last weekend and were disappointed not to see it through.
"We need to make amends tomorrow night. We face a difficult challenge; Sale are a good side with some great players so it will be a tough ask but one we are looking forward to."
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com