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Sale Sharks have drafted Cameron Shepherd into their starting line-up as they look to secure their first Aviva Premiership win of the season at the eighth time of asking.
The Australia international will make his first start for the Sharks since his summer arrival from Super Rugby outfit Western Force, which followed the collapse of a proposed move to Northampton.
Shepherd's inclusion on the left wing sees Mark Cueto switch to the right, with Tom Brady dropping to the bench.
The only other change from the side beaten at Worcester last time out sees Richie Gray come into the second row for Kearnan Myall.
For London Irish, Marland Yarde has recovered from injury and returns to the Exiles' starting XV on the left wing.
As a result, Sailosi Tagicakibau moves into the centres in place of the absent Jonathan Joseph, while Darren Allinson starts his first match of the season at scrum-half and will form a half-back partnership with Ian Humphreys.
Elsewhere, Scott Lawson starts at hooker and George Skivington is named as a replacement after recovering from injury.
Sale Sharks: 15 Nick Macleod, 14 Mark Cueto, 13 Johnny Leota, 12 Sam Tuitupou, 11 Cameron Shepherd, 10 Danny Cipriani, 9 Cillian Willis, 8 Andy Powell 7 David Seymour (capt ), 6 Richie Vernon, 5 Fraser McKenzie, 4 Richie Gray, 3 Tony Buckley, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Joe Ward, 17 Eifion Lewis-Roberts, 18 Vadim Cobilas, 19 Kearnan Myall, 20 Mark Easter, 21 Dwayne Peel, 22 Rob Miller, 23 Tom Brady
London Irish: 15 Anthony Watson, 14 Topsy Ojo, 13 Guy Armitage, 12 Sailosi Tagicakibau, 11 Marland Yarde, 10 Ian Humphreys, 9 Darren Allinson, 8 Chris Hala'ufia 7 Jamie Gibson, 6 Declan Danaher (Captain), 5 Matt Garvey, 4 Bryn Evans, 3 Halani Aulika, 2 Scott Lawson, 1 Max Lahiff.
Replacements: 16 Brian Blaney, 17 Cai Griffiths, 18 Leo Halavatau, 19 George Skivington, 20 Ofisa Treviranus, 21 Steven Shingler, 22 Shane Geraghty, 23 Jack Moates
"Friday evening will be a big test of how far we have come this season. We played some great rugby last weekend and were disappointed not to see it through.
"We need to make amends tomorrow night. We face a difficult challenge; Sale are a good side with some great players so it will be a tough ask but one we are looking forward to."
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|Friday 2nd May|
|19:45||Bath vs Northampton|
|Saturday 3rd May|
|15:00||Saracens vs Worcester|
|15:00||Wasps vs Newcastle|
|15:00||Gloucester vs London Irish|
|15:15||Sale vs Leicester|
|Sunday 4th May|
|14:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Leicester vs Saracens|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 20th April|
|Newcastle 18 - 23 Saracens|
|Northampton 36 - 21 London Irish|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
Read the thoughts and opinions of Stuart Barnes with skysports.com