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Saracens have made four changes to their starting XV for the Aviva Premiership clash with Northampton at stadiummk on Sunday.
Ernst Joubert comes in at No 8 to skipper the side as club captain Steve Borthwick is rested and his place in the second row taken by George Kruis, who switches from flanker.
Schalk Brits drops to the bench after the win against Bath last time out, with his place at hooker taken by fellow South African star John Smit.
Richard Wigglesworth and Owen Farrell also have to settle for spots on the bench as their respective places at scrum-half and inside centre are taken by Neil de Kock and Brad Barritt.
Andy Saull, Alex Goode, Jackson Wray, Alistair Hargreaves, Joe Maddock, Adam Powell, Jacques Burger and Justin Melck all miss the match through injury
Northampton also make four changes to their line-up following their 18-9 defeat to league leaders Harlequins, although three of those are made in the process of overhauling the front row.
Captain Dylan Hartley comes back in at hooker after serving a suspension and is joined by props Brian Mujati and Alex Waller. The remaining change sees Tom May replaced by Dom Waldouck at inside centre.
Sarries currently lie one point behind Quins at the Aviva Premiership summit while Northampton are two points outside the top four.
Saracens: 15 Chris Wyles, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 David Strettle, 10 Charlie Hodgson, 9 Neil de Kock, 8 Ernst Joubert (c), 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 George Kruis, 3 Matt Stevens, 2 John Smit, 1 Mako Vunipola.
Replacements: 16 Schalk Brits, 17 Rhys Gill, 18 Carlos Nieto, 19 Eoin Sheriff, 20 Jono Ross, 21 Richard Wigglesworth, 22 Owen Farrell, 23 James Short.
Northampton: 15 Ben Foden, 14 Ken Pisi, 13 George Pisi, 12 Dom Waldouck, 11 Jamie Elliott, 10 Stephen Myler, 9 Lee Dickson, 8 GJ Van Velze, 7 Phil Dowson, 6 Tom Wood, 5 Courtney Lawes, 4 Samu Manoa, 3 Brian Mujati, 2 Dylan Hartley (c), 1 Alex Waller.
Replacements: 16 Mike Haywood, 17 Soane Tonga'uiha, 18 Paul Doran Jones, 19 Mark Sorenson, 20 Calum Clark, 21 Martin Roberts, 22 Ryan Lamb, 23 Tom May.
"Things didn't go quite our way against Harlequins so everyone has been focused and determined in training this week.
"We certainly have a point to prove against Saracens, and we have the belief in the players' ability and desire to get a result in Milton Keynes.
"Saracens are one of the top teams in Europe, but we know that when we play at our best we are a match for anyone. So nothing less than a top performance will do as we look to end 2012 in a positive way."
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|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sale 21 - 20 Wasps|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
|Sunday 31st March|
|London Irish 33 - 33 Sale|
|Saturday 30th March|
|Worcester 18 - 24 Exeter|
|Northampton 8 - 36 Leicester|
|Wasps 13 - 22 Saracens|
|Bath 40 - 25 London Welsh|
Read the thoughts and opinions of Stuart Barnes with skysports.com