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Saracens enter their top-of-the-table clash with Harlequins on the back of three successive Aviva Premiership victories.
Defending champions Quins travel to the Allianz Park on Sunday looking to wipe out the four-point lead Saracens hold at the head of the table.
The hosts have scored twelve tries in their last three outings which have seen them leapfrog Harlequins, who lost to Exeter Chiefs in their last league encounter.
Harlequins do however enter the clash with momentum after lifting the LV Cup last weekend with victory against Sale Sharks, despite their England contingent being unavailable.
The timing of the clash sees both sides ring the changes as a number of key players return from international duty following the culmination of the Six Nations last weekend.
Saracens welcome back Alex Goode, Chris Ashton, Brad Barritt, Owen Farrell and Mako Vunipola from England duty, while Scotland captain Kelly Brown is also named in the starting line-up.
Farrell will start at fly-half which demotes Charlie Hodgson to the bench alongside John Smit, Neil de Kock and Chris Wyles.
Mike Brown, Danny Care, Joe Marler and captain Chris Robshaw all return to the Harlequins starting XV to face the league leaders.
Ugo Monye and Sam Smith begin on the wings for Harlequins with Matt Hopper and Jordan Turner-Hall partnered in the centres.
Joe Gray comes into the side at hooker as Charlie Matthews gets the nod in the second row alongside George Robson.
John Kingston's bench consists of eight players who all featured in the LV Cup final winning side last weekend.
Saracens: 15 Alex Goode, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 David Strettle, 10 Owen Farrell, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Will Fraser, 6 Kelly Brown, 5 Alistair Hargreaves, 4 Steve Borthwick (capt), 3 Matt Stevens, 2 Schalk Brits, 1 Mako Vunipola
Replacements: 16 John Smit, 17 Rhys Gill, 18 Petrus du Plessis, 19 George Kruis, 20 Jackson Wray, 21 Neil de Kock, 22 Charlie Hodgson, 23 Chris Wyles
Harlequins: 15 Mike Brown, 14 Ugo Monye, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Sam Smith, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (capt), 6 Tom Guest, 5 George Robson, 4 Charlie Matthews, 3 James Johnston, 2 Joe Gray, 1 Joe Marler
Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Will Collier, 19 Maurie Fa'asavalu, 20 Luke Wallace, 21 Karl Dickson, 22 Ben Botica, 23 George Lowe
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|Friday 2nd May|
|19:45||Bath vs Northampton|
|Saturday 3rd May|
|15:00||Saracens vs Worcester|
|15:00||Wasps vs Newcastle|
|15:00||Gloucester vs London Irish|
|15:15||Sale vs Leicester|
|Sunday 4th May|
|14:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Leicester vs Saracens|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 20th April|
|Newcastle 18 - 23 Saracens|
|Northampton 36 - 21 London Irish|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
Read the thoughts and opinions of Stuart Barnes with skysports.com