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London Welsh boss Lyn Jones has retained just five players for Saturday's Amlin Challenge Cup trip to face I Cavalieri Prato.
The Exiles' European debut last week was a nightmare - they were hammered 68-19 by Stade Francais at the Kassam Stadium.
In the backs, Joe Ajuwa, Seb Jewell, Simon Whatling and Gordon Ross all come in to the starting line-up.
Ryan Davis moves from inside centre to full-back, and Ross replaces Gavin Henson at fly-half.
Up front Martin Purdy, who spent two seasons in Italy with Gran Parma and L'Aquila makes his first start of the season.
There's also an entirely new back row with Ed Williamson, Michael Hills and Alfie To'oala coming into the side.
The Italians also had a terrible start to their Pool 5 campaign, losing 56-3 at Grenoble.
Their squad includes prop Guillermo Roan, who played for Welsh 14 times last season, whilst on loan from Wasps.
London Welsh: 15 Ryan Davis, 14 Joe Ajuwa, 13 Seb Jewell, 12 Simon Whatling, 11 Ashley Smith, 10 Gordon Ross, 9 Nick Runciman, 1 Tom Bristow, 2 Dan George, 3 Greg Bateman, 4 Kirill Kulemin, 5 Martin Purdy, 6 Ed Williamson, 7 Michael Hills, 8 Alfie To'oala.
Replacements: 16 Neil Briggs, 17 Billy Moss, 18 Paulica Ion, 19 Adam Brown, 20 Mike Denbee, 21 Matthew Keyte, 22 Alex Davies, 23 Nick Scott
Cavalieri: 15 Dion Berryman, 14 Billy Ngwaini, 13 Denis Majstorovic, 12 Ross Mccann, 11 Michele Sepe, 10 Riccardo Della Rossa, 9 Pino Patelli, 1 Alessandro Borsi, 2 Lorenzo Giovanchelli, 3 Guillermo Roan, 4 Agustin Cavalieri, 5 Giacomo Bernini, 6 Alberto Saccardo, 7 Luca Petillo, 8 Marco Pelizzari
Replacements: 16 Niccolò Cannone, 17 Renzo Balboni, 18 Alessandro Boscolo, 19 Edoardo Ruffolo, 20 Marco Frati, 21 Filippo Vezzosi, 22 Niccolò Tempestini, 23 Cosma Garfagnoli
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Read the thoughts and opinions of Stuart Barnes with skysports.com