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Wasps are the first visitors to Stadio Maurizio Quaggia in the Amlin Challenge Cup as they face Italians Mogliano on Sunday.
The Aviva Premiership club secured a bonus-point triumph over Newport Gwent Dragons in the opening round of matches in the competition, though they left it late to score a fourth try.
Joe Simpson crossed in injury time to finally get Dai Young's side a maximum haul after they had touched down three times in an impressive first half.
However scrum-half Simpson is rested for the trip to Italy, along with Billy Vunipola and Marco Wentzel.
Charlie Davies takes over at number nine while Elliot Daly, Andrea Masi and Christian Wade are all handed starting berths in the back line.
Lock James Cannon earns his first start this season in the place of vice-captain Wentzel; Tom Palmer is alongside him in the second row.
There are also places for prop Tim Payne and flanker James Haskell in the team, the latter's selection meaning Ashley Johnson moves to number eight.
Facing the two-time Heineken Cup champions is a tall order for Mogliano, particularly after they were thrashed 71-7 by Bayonne last time out. Flanker Marco Barbini did at least make history, grabbing their first try in Europe.
Mogliano: 15 Vittorio Candiago, 14 Alessandro Onori, 13 Enrico Ceccato, 12 Cristian Cerioni, 11 Ezio Galon, 10 Edoardo Padovani, 9 Alberto Lucchese, 1 Andrea Ceccato, 2 Ivan Gianesini, 3 Augusto Allori, 4 Federico Maso, 5 Enrico Pavanello, 6 Edoardo Candiago, 7 Meyer Swanepoel, 8 Mathew Gilbert
Replacements:16 Agustin Costa Repetto, 17 Davide Meggetto, 18 Laert Naka, 19 Nicola Corbanese, 20 Antonio Giabardo, 21 Filippo Guarducci, 22 Giovanni Benvenuti, 23 Marco Gazzola
London Wasps 15 Hugo Southwell, 14 Jack Wallace, 13 Elliott Daly, 12 Andrea Masi, 11 Christian Wade, 10 Nicky Robinson, 9 Charlie Davies; 1 Tim Payne, 2 T Rhys Thomas, 3 Fabio Staibano, 4 Tom Palmer, 5 James Cannon, 6 James Haskell, 7 Jonathan Poff, 8 Ashley Johnson
Replacements:16 Tom Lindsay, 17 Phil Swainston, 18 Zak Taulafo, 19 Joe Launchbury, 20 Sam Jones, 21 Jonah Holmes, 22 Stephen Jones, 23 Lee Thomas
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Read the thoughts and opinions of Stuart Barnes with skysports.com